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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016755802> ?p ?o ?g. }

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• W2016755802 abstract "The Toll-like receptors (TLRs) of the innate immune system detect host invasion by pathogens and initiate immune responses. All of the TLRs use the adaptor MyD88 to transduce a signal; however, two newly identified signaling molecules, TIRAP and TRIF, interact with a subset of the TLRs, suggesting a signaling specificity that may be relevant to the type of infection. Activation of the TRIF pathway, for example, leads to the production of antiviral gene products via the transcription factor, IRF3. In vivo experiments in TLR-deficient mice underscore the importance of TLRs in overcoming infection." @default.
• W2016755802 created "2016-06-24" @default.
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• W2016755802 date "2003-08-01" @default.
• W2016755802 modified "2023-10-13" @default.
• W2016755802 title "Recognition of microbial infection by Toll-like receptors" @default.
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• W2016755802 doi "https://doi.org/10.1016/s0952-7915(03)00080-3" @default.
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