FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016755952> ?p ?o ?g. }

• W2016755952 endingPage "149" @default.
• W2016755952 startingPage "142" @default.
• W2016755952 abstract "Studies on heterozygous (HZ) reeler mice suggest a relationship between reelin (a protein of extra cellular matrix) haploinsufficiency and the presence of altered neural networks and behaviour. Neonatal adverse and/or stimulating experiences might interfere with the emergence of this genetic-dependent phenotype. Repeated episodes of maternal separation early in ontogeny result in enduring neuroendocrine, neurochemical and behavioural alterations in the offspring. Therefore, in order to investigate whether developmental indexes of neurobehavioural disorders can be studied in the infant reeler mouse model, and whether ontogenetic adverse experiences may question or improve its suitability, homozygous reeler (RL), heterozygous (HZ) and wild-type (WT) mouse pups underwent maternal separation (SEP, 5 h/day) or handling (H, 3 min/day) on PND 2–6. As expected, a sex difference appeared, for measure of emotional and communicative behaviour in infant mice. On PND 7, compared to other genotypes, RL mouse pups from the H control group, showed reduced levels of ultrasound (USV) production and of locomotion. Surprisingly, this deficit in RL mice was fully reverted by maternal separation. Maternal separation per se reduced social motivation in the homing test at PND 9 in WT mice, with no effects on HZ and RL ones. Additionally, female pups emitted much lower levels of ultrasound production than males within the H control group. Such a baseline sex difference, however, disappeared in the SEP group. The present results provide evidence that unusual stress and related hormonal stimulation early in development may (i) independently shape individual phenotype and (ii) interact with a genetic make-up to substantially modify its “natural” developmental trajectories." @default.
• W2016755952 created "2016-06-24" @default.
• W2016755952 creator A5007959343 @default.
• W2016755952 creator A5010093730 @default.
• W2016755952 creator A5074270662 @default.
• W2016755952 creator A5091353919 @default.
• W2016755952 date "2007-02-01" @default.
• W2016755952 modified "2023-10-16" @default.
• W2016755952 title "Neurobehavioural disorders in the infant reeler mouse model: Interaction of genetic vulnerability and consequences of maternal separation" @default.
• W2016755952 cites W1966964537 @default.
• W2016755952 cites W1968226417 @default.
• W2016755952 cites W1971334707 @default.
• W2016755952 cites W1973281356 @default.
• W2016755952 cites W1976730655 @default.
• W2016755952 cites W1980713032 @default.
• W2016755952 cites W1984523180 @default.
• W2016755952 cites W1989700831 @default.
• W2016755952 cites W1990163657 @default.
• W2016755952 cites W1994517931 @default.
• W2016755952 cites W1995714241 @default.
• W2016755952 cites W2002806814 @default.
• W2016755952 cites W2010116458 @default.
• W2016755952 cites W2015629767 @default.
• W2016755952 cites W2019890913 @default.
• W2016755952 cites W2022428482 @default.
• W2016755952 cites W2026696795 @default.
• W2016755952 cites W2027760035 @default.
• W2016755952 cites W2029558151 @default.
• W2016755952 cites W2036442486 @default.
• W2016755952 cites W2036505090 @default.
• W2016755952 cites W2038743403 @default.
• W2016755952 cites W2049590417 @default.
• W2016755952 cites W2050818835 @default.
• W2016755952 cites W2054433767 @default.
• W2016755952 cites W2054692302 @default.
• W2016755952 cites W2056589483 @default.
• W2016755952 cites W2059022502 @default.
• W2016755952 cites W2060212335 @default.
• W2016755952 cites W2061040582 @default.
• W2016755952 cites W2062087581 @default.
• W2016755952 cites W2062235076 @default.
• W2016755952 cites W2062682953 @default.
• W2016755952 cites W2066171961 @default.
• W2016755952 cites W2067732599 @default.
• W2016755952 cites W2068758311 @default.
• W2016755952 cites W2069581520 @default.
• W2016755952 cites W2074154809 @default.
• W2016755952 cites W2081621134 @default.
• W2016755952 cites W2087209446 @default.
• W2016755952 cites W2087368034 @default.
• W2016755952 cites W2088937269 @default.
• W2016755952 cites W2091632458 @default.
• W2016755952 cites W2106354849 @default.
• W2016755952 cites W2112247320 @default.
• W2016755952 cites W2115535563 @default.
• W2016755952 cites W2127833287 @default.
• W2016755952 cites W2129279332 @default.
• W2016755952 cites W2141124547 @default.
• W2016755952 cites W2149917336 @default.
• W2016755952 cites W2151880531 @default.
• W2016755952 cites W2166334704 @default.
• W2016755952 cites W2324419367 @default.
• W2016755952 doi "https://doi.org/10.1016/j.bbr.2006.10.027" @default.
• W2016755952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17141885" @default.
• W2016755952 hasPublicationYear "2007" @default.
• W2016755952 type Work @default.
• W2016755952 sameAs 2016755952 @default.
• W2016755952 citedByCount "45" @default.
• W2016755952 countsByYear W20167559522012 @default.
• W2016755952 countsByYear W20167559522013 @default.
• W2016755952 countsByYear W20167559522014 @default.
• W2016755952 countsByYear W20167559522015 @default.
• W2016755952 countsByYear W20167559522016 @default.
• W2016755952 countsByYear W20167559522017 @default.
• W2016755952 countsByYear W20167559522019 @default.
• W2016755952 countsByYear W20167559522020 @default.
• W2016755952 countsByYear W20167559522022 @default.
• W2016755952 crossrefType "journal-article" @default.
• W2016755952 hasAuthorship W2016755952A5007959343 @default.
• W2016755952 hasAuthorship W2016755952A5010093730 @default.
• W2016755952 hasAuthorship W2016755952A5074270662 @default.
• W2016755952 hasAuthorship W2016755952A5091353919 @default.
• W2016755952 hasConcept C104317684 @default.
• W2016755952 hasConcept C112672928 @default.
• W2016755952 hasConcept C126322002 @default.
• W2016755952 hasConcept C127716648 @default.
• W2016755952 hasConcept C134018914 @default.
• W2016755952 hasConcept C138496976 @default.
• W2016755952 hasConcept C15744967 @default.
• W2016755952 hasConcept C169760540 @default.
• W2016755952 hasConcept C170493617 @default.
• W2016755952 hasConcept C25876315 @default.
• W2016755952 hasConcept C2777734550 @default.
• W2016755952 hasConcept C2778063154 @default.
• W2016755952 hasConcept C2779234561 @default.
• W2016755952 hasConcept C37291498 @default.
• W2016755952 hasConcept C50610925 @default.
• W2016755952 hasConcept C54355233 @default.

• next