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• W2016756486 abstract "The late editor of this journal, Professor Lars Erik Böttiger, wrote: ‘Drug treatment has changed rapidly in the last decades and has become more and more complicated. We give strong medicines with narrow therapeutic windows, we give many drugs concomitantly, with a risk for drug interactions, we treat for longer periods of times and our patients are getting older. Thus, the demands on doctors responsible for drug treatment have greatly increased’ [1]. This was in 1976. More than 30 years has passed since then, and the statement is even more true today. The number of drugs that any one patient is using is continuously increasing and thus so is the risk of unfavourable drug–drug interactions [2]. The drug–drug interaction database Swedish Finnish Interaction X-referencing, SFINX, contains more than 11 000 pairs of drugs that may possibly interact, and there are many examples of severe adverse and even fatal outcomes of drug–drug interactions. One example is severe arrythmia caused by the combination of a supposedly safe antihistamine, terfenadine, with erythromycin [3]. However, the total impact of drug–drug interactions in healthcare today, reflected in endpoints such as mortality, morbidity or measures of quality of life, remains largely unknown. This issue of the Journal of Internal Medicine includes several reviews, reflecting some of the contents of a symposium, held in June at the Swedish Society of Medicine, Stockholm, Sweden, entitled Drug–drug interactions – from research to clinical practice. The aim of the symposium was to present the latest research in the field of drug metabolism and transport, as a basis for pharmacokinetic drug interactions, to review some of the therapeutic areas in which drug interactions are of clear clinical importance and to discuss the regulatory, healthcare and research support available for the prescribers of today with respect to drug–drug interactions. Mackenzie and co-workers summarize current knowledge concerning drug–drug interactions within the area of cardiovascular prevention and, more specifically, antithrombotic treatment [4]. HIV is a chronic infection of worldwide prevalence, treated with the combinations of drugs with a high propensity for drug–drug interactions. The HIV population is also growing older and thus developing co-morbidities of various kinds. Josephson discusses the challenges of combining HIV therapy with the treatment of common conditions such as hyperlipidaemia, hypertension or asthma [5]. It is well known that drug–drug interactions may lead to severe side effects, but there is also an emerging awareness that these interactions may be just as likely to reduce drug efficacy. The problem of reduced formation of active metabolites because of drug–drug interactions is reviewed by Mannheimer and Eliasson [6]. No conflict of interest was declared." @default.
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• W2016756486 date "2010-11-22" @default.
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• W2016756486 title "Drug-drug interactions today - from research to clinical practice" @default.
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• W2016756486 doi "https://doi.org/10.1111/j.1365-2796.2010.02302.x" @default.
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