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- W2016758896 abstract "Nitrates have long been recognized as effective diuretics. Thomas Willis,<sup>1</sup>in 1679, used potassium nitrate or the salt of niter in the treatment of dropsy. Jörg,<sup>2</sup>in 1825, administered increasing doses of potassium nitrate to a normal man and noted its diuretic effect. Wood,<sup>3</sup>in 1856, confirmed the therapeutic action of nitrates, emphasizing the fact that an adequate dose was important in order to produce effective diuresis. Wilks and Taylor,<sup>4</sup>in 1863, gave as much as 18 Gm. of potassium nitrate a day to a patient with renal dropsy, obtaining satisfactory results. About twenty-five years ago the toxicity of nitrates became a practical problem because of the rather extensive use of bismuth subnitrate in diagnostic roentgen procedures. Cases presenting methemoglobinemia were reported<sup>5</sup>and consequently the possible toxic action of nitrates was overemphasized, with the resultant use of small and inadequate doses. Our previous experiments<sup>6</sup>and those of Gamble<sup>7</sup>showed that" @default.
- W2016758896 created "2016-06-24" @default.
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- W2016758896 date "1930-11-01" @default.
- W2016758896 modified "2023-10-18" @default.
- W2016758896 title "THE ACTION AND EXCRETION OF NITRATES" @default.
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- W2016758896 doi "https://doi.org/10.1001/archinte.1930.00140170058007" @default.
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