Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016768111> ?p ?o ?g. }
- W2016768111 endingPage "96" @default.
- W2016768111 startingPage "83" @default.
- W2016768111 abstract "Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due to the hypogenesis of cranial neural crest cells (NCCs). The derivatives of cranial NCCs, including the NCC-derived cell population of pharyngeal arches, craniofacial cartilage, pigment cells and the myocardium derived from cardiac NCCs, were affected in this mutant. The expression of several neural crest marker genes, including crestin, dlx2a and nrp2b, was specifically reduced in the cranial regions of the eif3ba mutant. Through fluorescence-tracing of the cranial NCC migration marker nrp2b, we observed reduced intensity of NCC-derived cells in the heart. In addition, p53 was markedly up-regulated in the eif3ba mutant embryos, which correlated with pronounced apoptosis in the cranial area as shown by TUNEL staining. These findings suggest a novel function of eif3ba during embryonic development and a novel level of regulation in the process of cranial NCC development, in addition to providing a potential animal model to mimic congenital diseases due to cranial NCC defects. Furthermore, we report the identification of a novel transgenic fish line Et(gata2a:EGFP)pku418 to trace the migration of cranial NCCs (including cardiac NCCs); this may serve as an invaluable tool for investigating the development and dynamics of cranial NCCs during zebrafish embryogenesis." @default.
- W2016768111 created "2016-06-24" @default.
- W2016768111 creator A5011877804 @default.
- W2016768111 creator A5015771440 @default.
- W2016768111 creator A5020612811 @default.
- W2016768111 creator A5026290865 @default.
- W2016768111 creator A5041221930 @default.
- W2016768111 creator A5047263441 @default.
- W2016768111 creator A5076473988 @default.
- W2016768111 creator A5087496453 @default.
- W2016768111 creator A5088942760 @default.
- W2016768111 creator A5091664162 @default.
- W2016768111 date "2013-09-01" @default.
- W2016768111 modified "2023-10-07" @default.
- W2016768111 title "Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish" @default.
- W2016768111 cites W1501608538 @default.
- W2016768111 cites W1533818248 @default.
- W2016768111 cites W1966987683 @default.
- W2016768111 cites W1969264016 @default.
- W2016768111 cites W1972741966 @default.
- W2016768111 cites W1980916535 @default.
- W2016768111 cites W1987863854 @default.
- W2016768111 cites W1989220791 @default.
- W2016768111 cites W2001237524 @default.
- W2016768111 cites W2001542282 @default.
- W2016768111 cites W2002398471 @default.
- W2016768111 cites W2008418565 @default.
- W2016768111 cites W2010660724 @default.
- W2016768111 cites W2010802977 @default.
- W2016768111 cites W2011317223 @default.
- W2016768111 cites W2012089946 @default.
- W2016768111 cites W2013391063 @default.
- W2016768111 cites W2016606965 @default.
- W2016768111 cites W2016643268 @default.
- W2016768111 cites W2017087414 @default.
- W2016768111 cites W2017301597 @default.
- W2016768111 cites W2017555426 @default.
- W2016768111 cites W2019529018 @default.
- W2016768111 cites W2020788680 @default.
- W2016768111 cites W2024054731 @default.
- W2016768111 cites W2030752860 @default.
- W2016768111 cites W2034806302 @default.
- W2016768111 cites W2038344065 @default.
- W2016768111 cites W2045090573 @default.
- W2016768111 cites W2047398286 @default.
- W2016768111 cites W2052361765 @default.
- W2016768111 cites W2054110614 @default.
- W2016768111 cites W2055191807 @default.
- W2016768111 cites W2057967850 @default.
- W2016768111 cites W2058084688 @default.
- W2016768111 cites W2059032864 @default.
- W2016768111 cites W2061377113 @default.
- W2016768111 cites W2064081765 @default.
- W2016768111 cites W2065757180 @default.
- W2016768111 cites W2077447565 @default.
- W2016768111 cites W2090020776 @default.
- W2016768111 cites W2091230390 @default.
- W2016768111 cites W2096251733 @default.
- W2016768111 cites W2103129642 @default.
- W2016768111 cites W2105352992 @default.
- W2016768111 cites W2109822989 @default.
- W2016768111 cites W2117163223 @default.
- W2016768111 cites W2119037821 @default.
- W2016768111 cites W2125349610 @default.
- W2016768111 cites W2131494614 @default.
- W2016768111 cites W2146982581 @default.
- W2016768111 cites W2148517656 @default.
- W2016768111 cites W2153482276 @default.
- W2016768111 cites W2162073604 @default.
- W2016768111 cites W2163083102 @default.
- W2016768111 cites W2165278884 @default.
- W2016768111 cites W2166996710 @default.
- W2016768111 cites W2168237808 @default.
- W2016768111 cites W2168614704 @default.
- W2016768111 cites W2169732876 @default.
- W2016768111 cites W2616707192 @default.
- W2016768111 cites W3143292036 @default.
- W2016768111 cites W4379089764 @default.
- W2016768111 doi "https://doi.org/10.1016/j.ydbio.2013.06.009" @default.
- W2016768111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23791820" @default.
- W2016768111 hasPublicationYear "2013" @default.
- W2016768111 type Work @default.
- W2016768111 sameAs 2016768111 @default.
- W2016768111 citedByCount "19" @default.
- W2016768111 countsByYear W20167681112014 @default.
- W2016768111 countsByYear W20167681112015 @default.
- W2016768111 countsByYear W20167681112017 @default.
- W2016768111 countsByYear W20167681112018 @default.
- W2016768111 countsByYear W20167681112019 @default.
- W2016768111 countsByYear W20167681112020 @default.
- W2016768111 countsByYear W20167681112021 @default.
- W2016768111 countsByYear W20167681112022 @default.
- W2016768111 countsByYear W20167681112023 @default.
- W2016768111 crossrefType "journal-article" @default.
- W2016768111 hasAuthorship W2016768111A5011877804 @default.
- W2016768111 hasAuthorship W2016768111A5015771440 @default.
- W2016768111 hasAuthorship W2016768111A5020612811 @default.
- W2016768111 hasAuthorship W2016768111A5026290865 @default.