FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016773564> ?p ?o ?g. }

• W2016773564 endingPage "105" @default.
• W2016773564 startingPage "94" @default.
• W2016773564 abstract "The assessment of the functional outcome - in addition to the conventional endpoints as histomorphometry of the ischemic brain damage - for the evaluation of cerebroprotective therapies is increasingly recommended, although there is little consensus on appropriate procedures. We evaluated a battery of sensorimotor tasks in rats after transient middle cerebral artery occlusion (MCAO) to select those with the highest potential to discriminate between various degrees of neuronal damage. A total of 40 Sprague-Dawley rats were subjected to 90 min of MCAO and assigned to one of four treatment arms: (1) sham-operated controls, (2) vehicle-treated controls, (3) moderately effective neuroprotection by 2x100 mg/kg alpha-phenyl-N-tert-butyl nitrone (PBN), (4) highly effective neuroprotection by mild hypothermia (33 degrees C). Functional deficits were daily quantified using the beam balance task (1.5 cm, 2.5 cm diameter rectangular and 2.5 cm diameter cylindrical beam), the prehensile traction task, the rotarod, and a six-point neuro-score. Infarction of cerebral cortex and basal ganglia was assessed one week after ischemia. Treatment with PBN significantly reduced cortical infarction (-31%), while treatment with hypothermia resulted in a significantly smaller infarct volume of cortex (-94%) and basal ganglia (-27%). Beam balance, prehensile traction and rotarod failed to demonstrate any difference in motor performance. The six-point neuro-score showed a significant correlation with cortical infarction from day 2 and with total infarct volume from day 3. The smaller the reduction of infarct volume, the later the corresponding difference in neuro-score became apparent. Functional outcome after MCAO in rats can be assessed by a relatively simple measurement of neurological deficit. The slope of functional recovery is closely related with the degree of the morphological, particularly cortical damage. If expected treatment effects are small, an observation period of at least 3 days should be planned for the study design. The functional impairment from focal brain ischemia and its subsequent recovery could provide valuable information for future studies evaluating the neuroprotective potential of novel agents and procedures." @default.
• W2016773564 created "2016-06-24" @default.
• W2016773564 creator A5010179037 @default.
• W2016773564 creator A5022698054 @default.
• W2016773564 creator A5023370991 @default.
• W2016773564 creator A5044978775 @default.
• W2016773564 creator A5060637371 @default.
• W2016773564 date "2000-04-01" @default.
• W2016773564 modified "2023-10-14" @default.
• W2016773564 title "Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms" @default.
• W2016773564 cites W1494950465 @default.
• W2016773564 cites W1889743606 @default.
• W2016773564 cites W1964543660 @default.
• W2016773564 cites W1964786617 @default.
• W2016773564 cites W1964923506 @default.
• W2016773564 cites W1965187012 @default.
• W2016773564 cites W1965623779 @default.
• W2016773564 cites W1970731526 @default.
• W2016773564 cites W1974879850 @default.
• W2016773564 cites W1976678881 @default.
• W2016773564 cites W1980874841 @default.
• W2016773564 cites W1983845697 @default.
• W2016773564 cites W1984305500 @default.
• W2016773564 cites W1984580618 @default.
• W2016773564 cites W1989014567 @default.
• W2016773564 cites W1994504422 @default.
• W2016773564 cites W1995003632 @default.
• W2016773564 cites W1996086345 @default.
• W2016773564 cites W1996660321 @default.
• W2016773564 cites W2000363938 @default.
• W2016773564 cites W2000592521 @default.
• W2016773564 cites W2000897030 @default.
• W2016773564 cites W2005444563 @default.
• W2016773564 cites W2010656523 @default.
• W2016773564 cites W2013499155 @default.
• W2016773564 cites W2013900800 @default.
• W2016773564 cites W2015607927 @default.
• W2016773564 cites W2025270165 @default.
• W2016773564 cites W2025326202 @default.
• W2016773564 cites W2028517578 @default.
• W2016773564 cites W2031776605 @default.
• W2016773564 cites W2033573399 @default.
• W2016773564 cites W2040038240 @default.
• W2016773564 cites W2041282921 @default.
• W2016773564 cites W2061686604 @default.
• W2016773564 cites W2063110006 @default.
• W2016773564 cites W2064198519 @default.
• W2016773564 cites W2065016050 @default.
• W2016773564 cites W2065723600 @default.
• W2016773564 cites W2067317555 @default.
• W2016773564 cites W2070949944 @default.
• W2016773564 cites W2074844876 @default.
• W2016773564 cites W2075453867 @default.
• W2016773564 cites W2080656191 @default.
• W2016773564 cites W2084470722 @default.
• W2016773564 cites W2085652502 @default.
• W2016773564 cites W2086635397 @default.
• W2016773564 cites W2093203706 @default.
• W2016773564 cites W2106051634 @default.
• W2016773564 cites W2112505121 @default.
• W2016773564 cites W2125683177 @default.
• W2016773564 cites W2127760221 @default.
• W2016773564 cites W2129658890 @default.
• W2016773564 cites W2130815585 @default.
• W2016773564 cites W2146082079 @default.
• W2016773564 cites W2146330634 @default.
• W2016773564 cites W2147783395 @default.
• W2016773564 cites W2166875348 @default.
• W2016773564 cites W4240511213 @default.
• W2016773564 doi "https://doi.org/10.1016/s0006-8993(00)02100-4" @default.
• W2016773564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10773197" @default.
• W2016773564 hasPublicationYear "2000" @default.
• W2016773564 type Work @default.
• W2016773564 sameAs 2016773564 @default.
• W2016773564 citedByCount "210" @default.
• W2016773564 countsByYear W20167735642012 @default.
• W2016773564 countsByYear W20167735642013 @default.
• W2016773564 countsByYear W20167735642014 @default.
• W2016773564 countsByYear W20167735642015 @default.
• W2016773564 countsByYear W20167735642016 @default.
• W2016773564 countsByYear W20167735642017 @default.
• W2016773564 countsByYear W20167735642018 @default.
• W2016773564 countsByYear W20167735642019 @default.
• W2016773564 countsByYear W20167735642020 @default.
• W2016773564 countsByYear W20167735642021 @default.
• W2016773564 countsByYear W20167735642022 @default.
• W2016773564 countsByYear W20167735642023 @default.
• W2016773564 crossrefType "journal-article" @default.
• W2016773564 hasAuthorship W2016773564A5010179037 @default.
• W2016773564 hasAuthorship W2016773564A5022698054 @default.
• W2016773564 hasAuthorship W2016773564A5023370991 @default.
• W2016773564 hasAuthorship W2016773564A5044978775 @default.
• W2016773564 hasAuthorship W2016773564A5060637371 @default.
• W2016773564 hasConcept C126322002 @default.
• W2016773564 hasConcept C127413603 @default.
• W2016773564 hasConcept C164705383 @default.
• W2016773564 hasConcept C25498285 @default.
• W2016773564 hasConcept C2775841333 @default.

• next