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• W2016788088 abstract "Peptide nucleic acids (PNAs) can bind to homopurine/ homopyrimidine sequences of double-stranded DNA targets in a sequence-specific manner and form [PNA] 2 /DNA triplexes with single-stranded DNA D-loop structures at the PNA binding sites. These D-loop structures have been found to have a capacity to initiate transcription in vitro . If this strategy can be used to induce transcription of endogenous genes, it may provide a novel approach for gene therapy of many human diseases. Human β globin disorders such as sickle cell anemia and β-thalassemia are very common genetic diseases that are caused by mutations in the β-globin gene. When γ-globin genes are highly expressed in sickle cell patients, the presence of high levels of fetal hemoglobin (HbF, α2γ2) can compensate for the defective β-globin gene product and such patients have much improved symptoms or are free of disease. However, the γ-globin genes are develop-mentally regulated and normally expressed at very low levels (>1%) in adult blood cells. We have investigated the possibility of inducing γ-globin gene expression with PNAs. Using PNAs designed to bind to the 5′ flanking region of the γ-globin gene, induction of expression of a reporter gene construct was demonstrated both in vitro and in vivo . More importantly, PNA-mediated induction of endogenous γ-globin gene expression was also demonstrated in K562 human erythroleukemia cells. This result suggests that induction of γ-globin gene expression with PNAs might provide a new approach for the treatment of sickle cell disease. PNA-induced gene expression strategy also may have implications in gene therapy of other diseases such as genetic diseases, cancer and infectious diseases." @default.
• W2016788088 created "2016-06-24" @default.
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• W2016788088 date "1999-07-01" @default.
• W2016788088 modified "2023-10-03" @default.
• W2016788088 title "Peptide nucleic acid (PNA) binding-mediated induction of human -globin gene expression" @default.
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• W2016788088 doi "https://doi.org/10.1093/nar/27.13.2806" @default.
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