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- W201679338 abstract "Measles virus infected cells express two virus specific antigens on their surface. These are the hemagglutinin (HA) and fusion (F1) polypeptides. Their turnover (half life) from the plasma membrane is 9 to 10 hours but in the presence of antibody, there is an initial rapid loss of F1 and HA followed by a slower phase in which T 1/2 is 12 to 15 hours. Reduced numbers of these surface viral antigens enable the cell to resist lysis by immune reagents. In addition, the loss of F1 molecules during antibody induced antigenic modulation accounts for the lack of both cell-cell fusion and giant cell formation by infected cells cultured with antibody. Expression of the internal phosphoprotein (P) and of the matrix or membrane (M) protein is also altered by antibody. These changes in P and M viral polypeptides are specific, since antibodies directed against measles virus antigens expressed on the cell's surface cause such effects but antibodies directed against nonviral antigens expressed on the surfaces of infected cells do not. Functionally, the P protein and its analogs in other viral systems appear to be associated with the transcriptive complex, whereas the M protein is associated with nucleocapsid recognition and alignment at the plasma membrane. Therefore, alterations in these polypeptides would lead to those aberrations in measles virus synthesis and maturation that are the observed hallmarks of persistent measles virus infection." @default.
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- W201679338 date "1980-01-01" @default.
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- W201679338 title "ANTIBODY-INDUCED MODULATION OF VIRAL ANTIGENS FROM INFECTED CELLS: BIOLOGICAL AND MOLECULAR STUDIES OF MEASLES VIRUS INFECTION AND IMPLICATIONS FOR UNDERSTANDING VIRUS PERSISTENCE AND RECEPTOR DISEASES" @default.
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