FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016794146> ?p ?o ?g. }

• W2016794146 endingPage "540" @default.
• W2016794146 startingPage "531" @default.
• W2016794146 abstract "Morphine relieves pain, in part, by acting on neurons within the periaqueductal gray (PAG). Given that the PAG contains a subpopulation of dopamine neurons, dopamine may contribute to the antinociceptive effects mediated by the PAG.This hypothesis was tested by measuring the behavioral and electrophysiological effects of administering dopamine agonists and antagonists into the ventrolateral PAG (vPAG). An initial histological experiment verified the existence of dopamine neurons within the vPAG using dopamine transporter and tyrosine hydroxylase antibodies visualized with confocal microscopy.Microinjection of cumulative doses of morphine into the vPAG caused antinociception that was dose-dependently inhibited by the dopamine receptor antagonist alpha-flupenthixol. alpha-Flupenthixol had no effect on nociception when administered alone. Injection of the dopamine receptor agonist (-) apomorphine into the vPAG caused a robust antinociception that was inhibited by the D2 antagonist eticlopride but not the D1 antagonist SCH-23390. The effects of dopamine on GABA(A)-mediated evoked inhibitory post-synaptic potentials (eIPSCs) were measured in PAG slices. Administration of met-enkephalin inhibited peak eIPSCs by 20-50%. Dopamine inhibited eIPSCs by approximately 20-25%. Administration of alpha-flupenthixol (20 muM) attenuated eIPSC inhibition by dopamine but had no effect on met-enkephalin-induced inhibition.These data indicate that PAG dopamine has a direct antinociceptive effect in addition to modulating the antinociceptive effect of morphine. The lack of an effect of alpha-flupenthixol on opioid-inhibition of eIPSCs indicates that this modulation occurs in parallel or subsequent to inhibition of GABA release." @default.
• W2016794146 created "2016-06-24" @default.
• W2016794146 creator A5004145125 @default.
• W2016794146 creator A5009666783 @default.
• W2016794146 creator A5031217639 @default.
• W2016794146 creator A5048853796 @default.
• W2016794146 date "2009-02-19" @default.
• W2016794146 modified "2023-10-16" @default.
• W2016794146 title "Contribution of dopamine receptors to periaqueductal gray-mediated antinociception" @default.
• W2016794146 cites W1523949186 @default.
• W2016794146 cites W1626809853 @default.
• W2016794146 cites W1901309030 @default.
• W2016794146 cites W1925492557 @default.
• W2016794146 cites W1965992579 @default.
• W2016794146 cites W1969509559 @default.
• W2016794146 cites W1983021998 @default.
• W2016794146 cites W1989644542 @default.
• W2016794146 cites W1996848646 @default.
• W2016794146 cites W1999089439 @default.
• W2016794146 cites W2003301993 @default.
• W2016794146 cites W2004222924 @default.
• W2016794146 cites W2005988907 @default.
• W2016794146 cites W2007284096 @default.
• W2016794146 cites W2009378556 @default.
• W2016794146 cites W2015290667 @default.
• W2016794146 cites W2022279619 @default.
• W2016794146 cites W2023079553 @default.
• W2016794146 cites W2023837052 @default.
• W2016794146 cites W2033824978 @default.
• W2016794146 cites W2035129861 @default.
• W2016794146 cites W2040653848 @default.
• W2016794146 cites W2047036720 @default.
• W2016794146 cites W2061540554 @default.
• W2016794146 cites W2061835446 @default.
• W2016794146 cites W2064950034 @default.
• W2016794146 cites W2067071952 @default.
• W2016794146 cites W2069218553 @default.
• W2016794146 cites W2078246592 @default.
• W2016794146 cites W2078964253 @default.
• W2016794146 cites W2079491525 @default.
• W2016794146 cites W2089602180 @default.
• W2016794146 cites W2090282154 @default.
• W2016794146 cites W2095326121 @default.
• W2016794146 cites W2103486522 @default.
• W2016794146 cites W2114641211 @default.
• W2016794146 cites W2116888010 @default.
• W2016794146 cites W2137863986 @default.
• W2016794146 cites W2151041079 @default.
• W2016794146 cites W2151233261 @default.
• W2016794146 cites W2165398609 @default.
• W2016794146 cites W2167049110 @default.
• W2016794146 cites W2172734677 @default.
• W2016794146 cites W4232095403 @default.
• W2016794146 cites W588205466 @default.
• W2016794146 doi "https://doi.org/10.1007/s00213-009-1482-y" @default.
• W2016794146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3399690" @default.
• W2016794146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19225762" @default.
• W2016794146 hasPublicationYear "2009" @default.
• W2016794146 type Work @default.
• W2016794146 sameAs 2016794146 @default.
• W2016794146 citedByCount "88" @default.
• W2016794146 countsByYear W20167941462012 @default.
• W2016794146 countsByYear W20167941462013 @default.
• W2016794146 countsByYear W20167941462014 @default.
• W2016794146 countsByYear W20167941462015 @default.
• W2016794146 countsByYear W20167941462016 @default.
• W2016794146 countsByYear W20167941462017 @default.
• W2016794146 countsByYear W20167941462018 @default.
• W2016794146 countsByYear W20167941462019 @default.
• W2016794146 countsByYear W20167941462020 @default.
• W2016794146 countsByYear W20167941462021 @default.
• W2016794146 countsByYear W20167941462022 @default.
• W2016794146 countsByYear W20167941462023 @default.
• W2016794146 crossrefType "journal-article" @default.
• W2016794146 hasAuthorship W2016794146A5004145125 @default.
• W2016794146 hasAuthorship W2016794146A5009666783 @default.
• W2016794146 hasAuthorship W2016794146A5031217639 @default.
• W2016794146 hasAuthorship W2016794146A5048853796 @default.
• W2016794146 hasBestOaLocation W20167941462 @default.
• W2016794146 hasConcept C120069818 @default.
• W2016794146 hasConcept C137183658 @default.
• W2016794146 hasConcept C169760540 @default.
• W2016794146 hasConcept C170493617 @default.
• W2016794146 hasConcept C185592680 @default.
• W2016794146 hasConcept C2776755682 @default.
• W2016794146 hasConcept C2777525119 @default.
• W2016794146 hasConcept C2781063702 @default.
• W2016794146 hasConcept C2781069035 @default.
• W2016794146 hasConcept C513476851 @default.
• W2016794146 hasConcept C529278444 @default.
• W2016794146 hasConcept C552161191 @default.
• W2016794146 hasConcept C55493867 @default.
• W2016794146 hasConcept C86803240 @default.
• W2016794146 hasConcept C98274493 @default.
• W2016794146 hasConceptScore W2016794146C120069818 @default.
• W2016794146 hasConceptScore W2016794146C137183658 @default.
• W2016794146 hasConceptScore W2016794146C169760540 @default.
• W2016794146 hasConceptScore W2016794146C170493617 @default.

• next