FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016795984> ?p ?o ?g. }

• W2016795984 endingPage "827" @default.
• W2016795984 startingPage "819" @default.
• W2016795984 abstract "The chronicity of hepatitis C virus (HCV) infection raises the question of how HCV is able to persist in hepatic cells. We show that human primary hepatocytes and human hepatic cell lines (Huh7 and HepG2) spontaneously produce interferon (IFN)-α that is inhibited in the HCV replicon cells (Huh.8 and FCA-1). Silencing IFN-α gene expression by IFN-α small interfering RNA (siRNA) in the HCV replicon cells resulted in increased HCV replicon expression. The activation of IFN-α expression by interferon regulatory factor (IRF-7) led to the inhibition of HCV replicon expression, whereas the anti–IFN-α receptor antibody could partially block IRF-7–mediated HCV replicon inhibition. In addition, the blockade of IFN-α receptor by anti–IFN-α receptor antibody on the replicon cells increased HCV replicon expression. Among the HCV nonstructural (NS) proteins tested, NS5A is the most potent inhibitor of IFN-α expression by the hepatic cells. Investigation of the mechanism of HCV action on IFN-α showed that IRF-7–induced IFN-α promoter activation was inhibited in the HCV replicon cells. Furthermore, IRF-7 expression was restricted in the HCV replicon cells. In conclusion, we provide direct evidence that HCV undermines the intracellular innate immunity of the target cells, which may account for HCV persistence in hepatic cells. (HEPATOLOGY 2005;42:00–00.) (HEPATOLOGY 2005;42:819–827.)" @default.
• W2016795984 created "2016-06-24" @default.
• W2016795984 creator A5003682597 @default.
• W2016795984 creator A5006086748 @default.
• W2016795984 creator A5009302189 @default.
• W2016795984 creator A5014327847 @default.
• W2016795984 creator A5026076336 @default.
• W2016795984 creator A5037161551 @default.
• W2016795984 creator A5046937419 @default.
• W2016795984 creator A5068438956 @default.
• W2016795984 creator A5069715775 @default.
• W2016795984 creator A5088174174 @default.
• W2016795984 date "2005-01-01" @default.
• W2016795984 modified "2023-10-16" @default.
• W2016795984 title "Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines" @default.
• W2016795984 cites W1515848954 @default.
• W2016795984 cites W1531074263 @default.
• W2016795984 cites W1531200550 @default.
• W2016795984 cites W1763230925 @default.
• W2016795984 cites W1968426124 @default.
• W2016795984 cites W1975764372 @default.
• W2016795984 cites W1982120218 @default.
• W2016795984 cites W1996856022 @default.
• W2016795984 cites W1998298315 @default.
• W2016795984 cites W2002301799 @default.
• W2016795984 cites W2009354010 @default.
• W2016795984 cites W2011678998 @default.
• W2016795984 cites W2012929232 @default.
• W2016795984 cites W2013816787 @default.
• W2016795984 cites W2026731669 @default.
• W2016795984 cites W2031770118 @default.
• W2016795984 cites W2032426302 @default.
• W2016795984 cites W2046714103 @default.
• W2016795984 cites W2056872110 @default.
• W2016795984 cites W2056970059 @default.
• W2016795984 cites W2059280966 @default.
• W2016795984 cites W2059457521 @default.
• W2016795984 cites W2063082801 @default.
• W2016795984 cites W2069376898 @default.
• W2016795984 cites W2071340959 @default.
• W2016795984 cites W2073675795 @default.
• W2016795984 cites W2078887917 @default.
• W2016795984 cites W2079295092 @default.
• W2016795984 cites W2089077517 @default.
• W2016795984 cites W2089738808 @default.
• W2016795984 cites W2092470099 @default.
• W2016795984 cites W2098676417 @default.
• W2016795984 cites W2101894411 @default.
• W2016795984 cites W2110217901 @default.
• W2016795984 cites W2114880462 @default.
• W2016795984 cites W2121381066 @default.
• W2016795984 cites W2125622337 @default.
• W2016795984 cites W2126153046 @default.
• W2016795984 cites W2135909641 @default.
• W2016795984 cites W2150368001 @default.
• W2016795984 cites W2151898297 @default.
• W2016795984 cites W2158697492 @default.
• W2016795984 cites W2159798757 @default.
• W2016795984 cites W2160063406 @default.
• W2016795984 cites W2165769699 @default.
• W2016795984 cites W2166086535 @default.
• W2016795984 cites W2170200856 @default.
• W2016795984 cites W2172292246 @default.
• W2016795984 cites W2175604459 @default.
• W2016795984 cites W30538912 @default.
• W2016795984 doi "https://doi.org/10.1002/hep.20854" @default.
• W2016795984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16175599" @default.
• W2016795984 hasPublicationYear "2005" @default.
• W2016795984 type Work @default.
• W2016795984 sameAs 2016795984 @default.
• W2016795984 citedByCount "53" @default.
• W2016795984 countsByYear W20167959842012 @default.
• W2016795984 countsByYear W20167959842013 @default.
• W2016795984 countsByYear W20167959842014 @default.
• W2016795984 countsByYear W20167959842015 @default.
• W2016795984 countsByYear W20167959842016 @default.
• W2016795984 countsByYear W20167959842017 @default.
• W2016795984 countsByYear W20167959842020 @default.
• W2016795984 countsByYear W20167959842021 @default.
• W2016795984 crossrefType "journal-article" @default.
• W2016795984 hasAuthorship W2016795984A5003682597 @default.
• W2016795984 hasAuthorship W2016795984A5006086748 @default.
• W2016795984 hasAuthorship W2016795984A5009302189 @default.
• W2016795984 hasAuthorship W2016795984A5014327847 @default.
• W2016795984 hasAuthorship W2016795984A5026076336 @default.
• W2016795984 hasAuthorship W2016795984A5037161551 @default.
• W2016795984 hasAuthorship W2016795984A5046937419 @default.
• W2016795984 hasAuthorship W2016795984A5068438956 @default.
• W2016795984 hasAuthorship W2016795984A5069715775 @default.
• W2016795984 hasAuthorship W2016795984A5088174174 @default.
• W2016795984 hasBestOaLocation W20167959841 @default.
• W2016795984 hasConcept C104317684 @default.
• W2016795984 hasConcept C126322002 @default.
• W2016795984 hasConcept C153911025 @default.
• W2016795984 hasConcept C159047783 @default.
• W2016795984 hasConcept C18103114 @default.
• W2016795984 hasConcept C22744801 @default.
• W2016795984 hasConcept C2522874641 @default.

• next