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• W2016799571 abstract "Two regulatory genes (lcoR and lcoS) were identified from a plasmid-borne lactococcal copper resistance determinant and characterized by transcriptional fusion to the promoterless chloramphenicol acetyltransferase gene (cat). RT-PCR analysis indicates that lcoR and lcoS are organized within an operon, controlling the transcription of cat in a copper-inducible manner. The amino acid sequences deduced from lcoR and lcoS show homology to the response and sensor proteins of known two-component regulatory systems. Deletion within either lcoS or both genes inactivated the copper-dependent activity, suggesting the presence of no trans-acting lcoR and lcoS homologs in the lactococcal host chromosome. The transcription start site involved in copper induction was mapped by primer extension." @default.
• W2016799571 created "2016-06-24" @default.
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• W2016799571 date "1999-03-01" @default.
• W2016799571 modified "2023-10-10" @default.
• W2016799571 title "A plasmid-encoded two-component regulatory system involved in copper-inducible transcription in Lactococcus lactis" @default.
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• W2016799571 doi "https://doi.org/10.1016/s0378-1119(98)00395-3" @default.
• W2016799571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10095123" @default.
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