Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016803072> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2016803072 abstract "Nonimmobilizers (inhaled compounds that do not suppress movement in response to a noxious stimulus) resemble anesthetics in their capacity to suppress memory, but unlike anesthetics, they can cause convulsions. Higher concentrations of nonimmobilizers may cause death, even with apparent suppression of convulsions by the concurrent administration of conventional inhaled anesthetics. We hypothesized that nonimmobilizers can depress ventilation and can cause death by adding to the depression of ventilation produced by conventional anesthetics. To test these hypotheses, we administered 1,2-dichlorohexafluorocyclobutane (2N) to four pigs anesthetized with desflurane. The addition of 2N decreased PaCO2 and tended to increase the slope of the ventilatory response to imposed increases in PETCO2. Limited results from study of two other nonimmobilizers (2,3-dichlorooctafluorobutane and perfluoropentane), in two pigs each, were consistent with the findings for 2N. However, experimental limitations (e.g., toxicity of 2,3-dichlorooctafluorobutane, and hypoxia from perfluoropentane) confound interpretation of these latter results. Our findings do not support our hypotheses--2N (and presumably all nonimmobilizers) seems to be a respiratory stimulant, not a depressant.A new class of inhaled compounds, nonimmobilizers, allow tests of how inhaled anesthetics act. Nonimmobilizers may act like anesthetics (e.g., impair learning) or may not (e.g., do not prevent movement in response to a noxious stimulus). The present work shows that, unlike anesthetics,nonimmobilizers do not depress breathing." @default.
- W2016803072 created "2016-06-24" @default.
- W2016803072 creator A5006880359 @default.
- W2016803072 creator A5018442699 @default.
- W2016803072 creator A5026287401 @default.
- W2016803072 creator A5034712411 @default.
- W2016803072 creator A5088543192 @default.
- W2016803072 date "1998-01-01" @default.
- W2016803072 modified "2023-10-16" @default.
- W2016803072 title "Ventilatory Effects of the Nonimmobilizer 1,2-Dichlorohexafluorocyclobutane (2N) in Swine" @default.
- W2016803072 cites W1966736164 @default.
- W2016803072 cites W1984180589 @default.
- W2016803072 cites W1988057482 @default.
- W2016803072 cites W2021015993 @default.
- W2016803072 cites W2037158680 @default.
- W2016803072 cites W2049587507 @default.
- W2016803072 cites W2058009321 @default.
- W2016803072 cites W2065946845 @default.
- W2016803072 cites W2069570693 @default.
- W2016803072 cites W2082552026 @default.
- W2016803072 cites W2260551612 @default.
- W2016803072 doi "https://doi.org/10.1097/00000539-199801000-00034" @default.
- W2016803072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9428874" @default.
- W2016803072 hasPublicationYear "1998" @default.
- W2016803072 type Work @default.
- W2016803072 sameAs 2016803072 @default.
- W2016803072 citedByCount "2" @default.
- W2016803072 crossrefType "journal-article" @default.
- W2016803072 hasAuthorship W2016803072A5006880359 @default.
- W2016803072 hasAuthorship W2016803072A5018442699 @default.
- W2016803072 hasAuthorship W2016803072A5026287401 @default.
- W2016803072 hasAuthorship W2016803072A5034712411 @default.
- W2016803072 hasAuthorship W2016803072A5088543192 @default.
- W2016803072 hasBestOaLocation W20168030721 @default.
- W2016803072 hasConcept C104211972 @default.
- W2016803072 hasConcept C126322002 @default.
- W2016803072 hasConcept C127413603 @default.
- W2016803072 hasConcept C15490471 @default.
- W2016803072 hasConcept C15744967 @default.
- W2016803072 hasConcept C170493617 @default.
- W2016803072 hasConcept C178790620 @default.
- W2016803072 hasConcept C185592680 @default.
- W2016803072 hasConcept C200457457 @default.
- W2016803072 hasConcept C2778162923 @default.
- W2016803072 hasConcept C2779918689 @default.
- W2016803072 hasConcept C2910438640 @default.
- W2016803072 hasConcept C42219234 @default.
- W2016803072 hasConcept C534529494 @default.
- W2016803072 hasConcept C540031477 @default.
- W2016803072 hasConcept C542102704 @default.
- W2016803072 hasConcept C71924100 @default.
- W2016803072 hasConcept C7836513 @default.
- W2016803072 hasConcept C78519656 @default.
- W2016803072 hasConcept C98274493 @default.
- W2016803072 hasConceptScore W2016803072C104211972 @default.
- W2016803072 hasConceptScore W2016803072C126322002 @default.
- W2016803072 hasConceptScore W2016803072C127413603 @default.
- W2016803072 hasConceptScore W2016803072C15490471 @default.
- W2016803072 hasConceptScore W2016803072C15744967 @default.
- W2016803072 hasConceptScore W2016803072C170493617 @default.
- W2016803072 hasConceptScore W2016803072C178790620 @default.
- W2016803072 hasConceptScore W2016803072C185592680 @default.
- W2016803072 hasConceptScore W2016803072C200457457 @default.
- W2016803072 hasConceptScore W2016803072C2778162923 @default.
- W2016803072 hasConceptScore W2016803072C2779918689 @default.
- W2016803072 hasConceptScore W2016803072C2910438640 @default.
- W2016803072 hasConceptScore W2016803072C42219234 @default.
- W2016803072 hasConceptScore W2016803072C534529494 @default.
- W2016803072 hasConceptScore W2016803072C540031477 @default.
- W2016803072 hasConceptScore W2016803072C542102704 @default.
- W2016803072 hasConceptScore W2016803072C71924100 @default.
- W2016803072 hasConceptScore W2016803072C7836513 @default.
- W2016803072 hasConceptScore W2016803072C78519656 @default.
- W2016803072 hasConceptScore W2016803072C98274493 @default.
- W2016803072 hasLocation W20168030721 @default.
- W2016803072 hasLocation W20168030722 @default.
- W2016803072 hasOpenAccess W2016803072 @default.
- W2016803072 hasPrimaryLocation W20168030721 @default.
- W2016803072 hasRelatedWork W173265678 @default.
- W2016803072 hasRelatedWork W1982121566 @default.
- W2016803072 hasRelatedWork W2009271917 @default.
- W2016803072 hasRelatedWork W2013013378 @default.
- W2016803072 hasRelatedWork W2023919652 @default.
- W2016803072 hasRelatedWork W2030306980 @default.
- W2016803072 hasRelatedWork W2037755837 @default.
- W2016803072 hasRelatedWork W2041347169 @default.
- W2016803072 hasRelatedWork W2087969896 @default.
- W2016803072 hasRelatedWork W4200199146 @default.
- W2016803072 isParatext "false" @default.
- W2016803072 isRetracted "false" @default.
- W2016803072 magId "2016803072" @default.
- W2016803072 workType "article" @default.