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- W2016804110 abstract "Around the world, trypanosomatids are known for being etiological agents of several highly disabling and often fatal diseases like Chagas disease ( Trypanosoma cruzi ), leishmaniasis ( Leishmania spp.), and African trypanosomiasis ( Trypanosoma brucei ). Throughout their life cycle, they must cope with diverse environmental conditions, and the mechanisms involved in these processes are crucial for their survival. In this review, we describe the role of heme in several essential metabolic pathways of these protozoans. Notwithstanding trypanosomatids lack of the complete heme biosynthetic pathway, we focus our discussion in the metabolic role played for important heme-proteins, like cytochromes. Although several genes for different types of cytochromes, involved in mitochondrial respiration, polyunsaturated fatty acid metabolism, and sterol biosynthesis, are annotated at the Tritryp Genome Project, the encoded proteins have not yet been deeply studied. We pointed our attention into relevant aspects of these protein functions that are amenable to be considered for rational design of trypanocidal agents." @default.
- W2016804110 created "2016-06-24" @default.
- W2016804110 creator A5005627229 @default.
- W2016804110 creator A5019035614 @default.
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- W2016804110 date "2011-04-10" @default.
- W2016804110 modified "2023-10-18" @default.
- W2016804110 title "Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways" @default.
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- W2016804110 doi "https://doi.org/10.4061/2011/873230" @default.
- W2016804110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3092630" @default.
- W2016804110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21603276" @default.
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