Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016804919> ?p ?o ?g. }
- W2016804919 endingPage "182" @default.
- W2016804919 startingPage "170" @default.
- W2016804919 abstract "MICA is a stress-regulated molecule recognized by the NK cell-activating receptor NKG2D. Previously, we demonstrated that MICA is induced on activated T cells but regulation by mitogenic cytokines and its biological consequences remain unexplored. Here, we show that IL-2, IL-4, and IL-15 but not TNF-α or IFN-α induced MICA expression in T lymphocytes present in peripheral blood mononuclear cells (PBMCs), as assessed by Western blot. IL-2 effect involved Jak3/STAT5, p38 MAPK, p7056 kinase, Lck/fyn kinases, and NF-κB. MICA expression was also observed in Th1 and Th2 cells. However, surface expression was not detected. T lymphocytes present in PBMCs and isolated CD4+ T lymphocytes stimulated with phorbol-12-myristate-13-acetate and ionomycin also induced MICA expression as assessed by Western blot, but only low levels were expressed at the cell surface. Activated but not resting CD4+ T lymphocytes were lysed by IL-15- or IL-2-stimulated NK cells, and susceptibility was increased when HLA class I molecules were blocked. Also, cytokine-stimulated NK cells produced more IFN-γ after culture with activated CD4+ T lymphocytes. However, the participation of MICA in these responses, if any, was marginal. Confocal microscopy revealed that MICA is retained mostly inside activated CD4+ T cells. Our results suggest that low surface expression of MICA on activated CD4+ T lymphocytes might be a safeguard mechanism to protect them from NK cells in an inflammatory, virus-infected, or tumor microenvironment, where NK and activated CD4+ T cells are recruited." @default.
- W2016804919 created "2016-06-24" @default.
- W2016804919 creator A5010554915 @default.
- W2016804919 creator A5024233653 @default.
- W2016804919 creator A5024637733 @default.
- W2016804919 creator A5042397069 @default.
- W2016804919 creator A5056037326 @default.
- W2016804919 creator A5069991162 @default.
- W2016804919 date "2006-03-01" @default.
- W2016804919 modified "2023-09-26" @default.
- W2016804919 title "Intracellular Expression of MICA in Activated CD4 T Lymphocytes and Protection from NK Cell-Mediated MICA-Dependent Cytotoxicity" @default.
- W2016804919 cites W1491881321 @default.
- W2016804919 cites W1532737852 @default.
- W2016804919 cites W1658020800 @default.
- W2016804919 cites W1975571037 @default.
- W2016804919 cites W1976510602 @default.
- W2016804919 cites W1987468632 @default.
- W2016804919 cites W1992959382 @default.
- W2016804919 cites W1993786192 @default.
- W2016804919 cites W1999341606 @default.
- W2016804919 cites W2000070744 @default.
- W2016804919 cites W2010428440 @default.
- W2016804919 cites W2023144585 @default.
- W2016804919 cites W2023370541 @default.
- W2016804919 cites W2024742663 @default.
- W2016804919 cites W2056204715 @default.
- W2016804919 cites W2067437716 @default.
- W2016804919 cites W2070780262 @default.
- W2016804919 cites W2077980628 @default.
- W2016804919 cites W2079683856 @default.
- W2016804919 cites W2084292672 @default.
- W2016804919 cites W2093757915 @default.
- W2016804919 cites W2094861927 @default.
- W2016804919 cites W2096668238 @default.
- W2016804919 cites W2102201839 @default.
- W2016804919 cites W2112129363 @default.
- W2016804919 cites W2119333066 @default.
- W2016804919 cites W2124829718 @default.
- W2016804919 cites W2131053525 @default.
- W2016804919 cites W2137538026 @default.
- W2016804919 cites W2159771756 @default.
- W2016804919 cites W2170069789 @default.
- W2016804919 doi "https://doi.org/10.1016/j.humimm.2006.02.010" @default.
- W2016804919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16698439" @default.
- W2016804919 hasPublicationYear "2006" @default.
- W2016804919 type Work @default.
- W2016804919 sameAs 2016804919 @default.
- W2016804919 citedByCount "35" @default.
- W2016804919 countsByYear W20168049192012 @default.
- W2016804919 countsByYear W20168049192013 @default.
- W2016804919 countsByYear W20168049192014 @default.
- W2016804919 countsByYear W20168049192015 @default.
- W2016804919 countsByYear W20168049192016 @default.
- W2016804919 countsByYear W20168049192017 @default.
- W2016804919 countsByYear W20168049192018 @default.
- W2016804919 countsByYear W20168049192020 @default.
- W2016804919 countsByYear W20168049192022 @default.
- W2016804919 countsByYear W20168049192023 @default.
- W2016804919 crossrefType "journal-article" @default.
- W2016804919 hasAuthorship W2016804919A5010554915 @default.
- W2016804919 hasAuthorship W2016804919A5024233653 @default.
- W2016804919 hasAuthorship W2016804919A5024637733 @default.
- W2016804919 hasAuthorship W2016804919A5042397069 @default.
- W2016804919 hasAuthorship W2016804919A5056037326 @default.
- W2016804919 hasAuthorship W2016804919A5069991162 @default.
- W2016804919 hasConcept C129374314 @default.
- W2016804919 hasConcept C149532602 @default.
- W2016804919 hasConcept C153911025 @default.
- W2016804919 hasConcept C154317977 @default.
- W2016804919 hasConcept C167672396 @default.
- W2016804919 hasConcept C183193105 @default.
- W2016804919 hasConcept C185592680 @default.
- W2016804919 hasConcept C202751555 @default.
- W2016804919 hasConcept C203014093 @default.
- W2016804919 hasConcept C2776062744 @default.
- W2016804919 hasConcept C2776090121 @default.
- W2016804919 hasConcept C2776989580 @default.
- W2016804919 hasConcept C2778867473 @default.
- W2016804919 hasConcept C55493867 @default.
- W2016804919 hasConcept C79879829 @default.
- W2016804919 hasConcept C86803240 @default.
- W2016804919 hasConcept C8891405 @default.
- W2016804919 hasConcept C95444343 @default.
- W2016804919 hasConceptScore W2016804919C129374314 @default.
- W2016804919 hasConceptScore W2016804919C149532602 @default.
- W2016804919 hasConceptScore W2016804919C153911025 @default.
- W2016804919 hasConceptScore W2016804919C154317977 @default.
- W2016804919 hasConceptScore W2016804919C167672396 @default.
- W2016804919 hasConceptScore W2016804919C183193105 @default.
- W2016804919 hasConceptScore W2016804919C185592680 @default.
- W2016804919 hasConceptScore W2016804919C202751555 @default.
- W2016804919 hasConceptScore W2016804919C203014093 @default.
- W2016804919 hasConceptScore W2016804919C2776062744 @default.
- W2016804919 hasConceptScore W2016804919C2776090121 @default.
- W2016804919 hasConceptScore W2016804919C2776989580 @default.
- W2016804919 hasConceptScore W2016804919C2778867473 @default.
- W2016804919 hasConceptScore W2016804919C55493867 @default.
- W2016804919 hasConceptScore W2016804919C79879829 @default.