Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016805202> ?p ?o ?g. }
- W2016805202 endingPage "176" @default.
- W2016805202 startingPage "167" @default.
- W2016805202 abstract "Within cells, retinol (ROL) is bound to cytoplasmic proteins (cellular retinol-binding proteins [CRBPs]), whose proposed function is to protect it from unspecific enzymes through channeling to retinoid-metabolizing pathways. We show that, during development, ROL and retinyl ester levels are decreased in CRBP type 1 (CRBP1) -deficient embryos and fetuses by 50% and 80%, respectively. The steady state level of retinoic acid (RA) is also decreased but to a lesser extent. However, CRBP1-null fetuses do not exhibit the abnormalities characteristic of a vitamin A-deficiency syndrome. Neither CRBP1 deficiency alters the expression patterns of RA-responding genes during development, nor does CRBP1 availability modify the expression of an RA-dependent gene in primary embryonic fibroblasts treated with ROL. Therefore, CRBP1 is required in prenatal life to maintain normal amounts of ROL and to ensure its efficient storage but seems of secondary importance for RA synthesis, at least under conditions of maternal vitamin A sufficiency." @default.
- W2016805202 created "2016-06-24" @default.
- W2016805202 creator A5001984770 @default.
- W2016805202 creator A5005298399 @default.
- W2016805202 creator A5007529650 @default.
- W2016805202 creator A5008459874 @default.
- W2016805202 creator A5021536776 @default.
- W2016805202 creator A5026995646 @default.
- W2016805202 creator A5035997748 @default.
- W2016805202 creator A5085761422 @default.
- W2016805202 date "2005-03-11" @default.
- W2016805202 modified "2023-10-11" @default.
- W2016805202 title "Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development" @default.
- W2016805202 cites W1492410406 @default.
- W2016805202 cites W1505014554 @default.
- W2016805202 cites W1539050811 @default.
- W2016805202 cites W1548460103 @default.
- W2016805202 cites W1548641817 @default.
- W2016805202 cites W1573150919 @default.
- W2016805202 cites W1580518357 @default.
- W2016805202 cites W1634449047 @default.
- W2016805202 cites W1854733189 @default.
- W2016805202 cites W1910466034 @default.
- W2016805202 cites W1911871301 @default.
- W2016805202 cites W1927684145 @default.
- W2016805202 cites W1936962732 @default.
- W2016805202 cites W1974296240 @default.
- W2016805202 cites W1976506214 @default.
- W2016805202 cites W1978691650 @default.
- W2016805202 cites W1981279981 @default.
- W2016805202 cites W1981717373 @default.
- W2016805202 cites W1985925832 @default.
- W2016805202 cites W1990895444 @default.
- W2016805202 cites W1992110513 @default.
- W2016805202 cites W1993045841 @default.
- W2016805202 cites W1995754186 @default.
- W2016805202 cites W1998861020 @default.
- W2016805202 cites W2002529271 @default.
- W2016805202 cites W2002566107 @default.
- W2016805202 cites W2004798737 @default.
- W2016805202 cites W2005883936 @default.
- W2016805202 cites W2016392505 @default.
- W2016805202 cites W2019631619 @default.
- W2016805202 cites W2023023843 @default.
- W2016805202 cites W2023895471 @default.
- W2016805202 cites W2025631499 @default.
- W2016805202 cites W2026610662 @default.
- W2016805202 cites W2027736032 @default.
- W2016805202 cites W2040046771 @default.
- W2016805202 cites W2045935078 @default.
- W2016805202 cites W2053078554 @default.
- W2016805202 cites W2069710660 @default.
- W2016805202 cites W2073020869 @default.
- W2016805202 cites W2074038170 @default.
- W2016805202 cites W2089338516 @default.
- W2016805202 cites W2090260875 @default.
- W2016805202 cites W2092488865 @default.
- W2016805202 cites W2093094881 @default.
- W2016805202 cites W2094210840 @default.
- W2016805202 cites W2103440968 @default.
- W2016805202 cites W2104030002 @default.
- W2016805202 cites W2114145258 @default.
- W2016805202 cites W2124676027 @default.
- W2016805202 cites W2138434278 @default.
- W2016805202 cites W2165108884 @default.
- W2016805202 cites W2187179434 @default.
- W2016805202 cites W2202569420 @default.
- W2016805202 cites W2254919660 @default.
- W2016805202 cites W2274838920 @default.
- W2016805202 cites W2291668409 @default.
- W2016805202 doi "https://doi.org/10.1002/dvdy.20313" @default.
- W2016805202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15765518" @default.
- W2016805202 hasPublicationYear "2005" @default.
- W2016805202 type Work @default.
- W2016805202 sameAs 2016805202 @default.
- W2016805202 citedByCount "39" @default.
- W2016805202 countsByYear W20168052022012 @default.
- W2016805202 countsByYear W20168052022013 @default.
- W2016805202 countsByYear W20168052022014 @default.
- W2016805202 countsByYear W20168052022015 @default.
- W2016805202 countsByYear W20168052022017 @default.
- W2016805202 countsByYear W20168052022018 @default.
- W2016805202 countsByYear W20168052022019 @default.
- W2016805202 countsByYear W20168052022020 @default.
- W2016805202 countsByYear W20168052022021 @default.
- W2016805202 countsByYear W20168052022022 @default.
- W2016805202 countsByYear W20168052022023 @default.
- W2016805202 crossrefType "journal-article" @default.
- W2016805202 hasAuthorship W2016805202A5001984770 @default.
- W2016805202 hasAuthorship W2016805202A5005298399 @default.
- W2016805202 hasAuthorship W2016805202A5007529650 @default.
- W2016805202 hasAuthorship W2016805202A5008459874 @default.
- W2016805202 hasAuthorship W2016805202A5021536776 @default.
- W2016805202 hasAuthorship W2016805202A5026995646 @default.
- W2016805202 hasAuthorship W2016805202A5035997748 @default.
- W2016805202 hasAuthorship W2016805202A5085761422 @default.
- W2016805202 hasConcept C104317684 @default.
- W2016805202 hasConcept C126322002 @default.