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- W2016805596 abstract "The SS, RR and meso stereoisomers of pyranenamine SK&F 84210 were synthesized stereospecifically starting from commercially available (R)-(-)- or (S)-(+)-2,2-dimethyl-1,3-dioxolane-4-methanol. In addition, two achiral pyranenamines 19 and 26 were also synthesized. When evaluated by intravenous and topical routes in the rat passive ocular anaphylaxis (POA) assay, (SS)- and meso-2 as well as achiral compounds 19 and 26 were found to be more potent antiallergic agents than (RR)-2." @default.
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- W2016805596 date "1991-01-01" @default.
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- W2016805596 title "Synthesis of chiral and achiral pyranenamine derivatives. Potent agents with topical ocular antiallergic activity" @default.
- W2016805596 doi "https://doi.org/10.1021/jm00105a060" @default.
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