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- W2016806057 abstract "The effects of ryanodine in a cloned human cardiac potassium channel (hKv1.5) expressed in a stable mouse L cell line was studied using whole cell voltage clamp technique. Ryanodine in a dose dependent manner (10−7−10−5 M) reduced the peak current as well as the current at the end of a 250 ms pulse. Dose response data fitted to a Hill equation yielded IC50 of 1.2 μm. The degree of block was not voltage dependent. Peak current was reduced from 43.6 ± 12.5% at 10−5m to 11.3 ± 4.8% at 10−7m ryanodine. Ryanodine reduced the tail current amplitude without changing the time course relative to the control. The inhibition was only partially reversible at concentrations below 10−6m." @default.
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- W2016806057 title "Ryanodine induced block of a cloned human cardiac potassium channel" @default.
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- W2016806057 doi "https://doi.org/10.1016/0022-2828(95)90015-2" @default.
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