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- W2016810487 abstract "There is some indication that anti-opiate peptides (AOP) modulate opioid receptor systems by altering μ-receptor density. To further characterize this phenomenon, we investigated the effects of continuous infusion of anti-AOP IgG on μ binding sites in the brains of rats. Specifically, male Sprague–Dawley rats received intracerebroventricular (ICV) infusions for 13 days of either control (rabbit) IgG or test IgGs: anti-dynorphin A IgG, anti-dynorphin A1–8 IgG, anti-α-MSH IgG, or the monoclonal anti-NPFF IgG. Administration of anti-NPFF IgG or the anti-dynorphin1–8 IgG significantly increased μ labeling by 40–70% in several brain regions at the caudate level. Contrary to these findings, anti-α-MSH IgG decreased (19–32%) [125I]-DAMGO labeling in several thalamic nuclei. The results suggest that the density of μ-opioid receptors is regulated in part by anti-opiate peptides in the extracellular fluid of the brain." @default.
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- W2016810487 date "1998-01-01" @default.
- W2016810487 modified "2023-09-23" @default.
- W2016810487 title "Regulation of μ binding sites after chronic administration of antibodies directed against specific anti-opiate peptides" @default.
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- W2016810487 doi "https://doi.org/10.1016/s0196-9781(98)00121-1" @default.
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