Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016821035> ?p ?o ?g. }
- W2016821035 endingPage "229" @default.
- W2016821035 startingPage "221" @default.
- W2016821035 abstract "We previously reported that orthovanadate composed of vanadate (V(5+)) activates phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling through inhibition of protein tyrosine phosphatases, thereby eliciting neuroprotection in brain ischemia/reperfusion injury. However, therapeutic doses of orthovanadate are associated with diarrhea due to inhibition of ATPase. By contrast, vanadyl (V(4+)) organic compounds show low cytotoxicity. Since both vanadate and vanadyl inhibit protein tyrosine phosphatases, we tested whether bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) [VO(OPT)] in a vanadyl form elicits a neuroprotection in brain ischemia. In a mouse transient middle cerebral artery occlusion (MCAO) model, pre- and post-treatments with VO(OPT) significantly reduced infarct volume in a dose-dependent manner. Like orthovanadate, activation of the PI3K/Akt pathway mediated neuroprotective action. VO(OPT) treatment inhibited reduced Akt phosphorylation at Ser-473 following brain ischemia and restored decreased phosphorylation of forkhead box class O (FOXO) family members such as FKHR, FKHRL1, and AFX. Consistent with inhibition of FOXO dephosphorylation, VO(OPT) treatment blocked elevated expression of Fas-ligand, Bim and active caspase-3 24 h after ischemia/reperfusion. Taken together, a vanadyl compound, VO(OPT) elicits neuroprotective effects on brain ischemia/reperfusion injury without apparent side effects." @default.
- W2016821035 created "2016-06-24" @default.
- W2016821035 creator A5020212173 @default.
- W2016821035 creator A5025354885 @default.
- W2016821035 creator A5036487279 @default.
- W2016821035 creator A5053088987 @default.
- W2016821035 creator A5055184036 @default.
- W2016821035 creator A5062220638 @default.
- W2016821035 creator A5091324614 @default.
- W2016821035 date "2007-08-01" @default.
- W2016821035 modified "2023-10-16" @default.
- W2016821035 title "Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia" @default.
- W2016821035 cites W1518531861 @default.
- W2016821035 cites W1520021552 @default.
- W2016821035 cites W1528985492 @default.
- W2016821035 cites W1578058970 @default.
- W2016821035 cites W1972931383 @default.
- W2016821035 cites W1973109581 @default.
- W2016821035 cites W1973342484 @default.
- W2016821035 cites W1979147887 @default.
- W2016821035 cites W1985671816 @default.
- W2016821035 cites W1995630012 @default.
- W2016821035 cites W2001246952 @default.
- W2016821035 cites W2006242402 @default.
- W2016821035 cites W2008474840 @default.
- W2016821035 cites W2011785467 @default.
- W2016821035 cites W2016730049 @default.
- W2016821035 cites W2023812320 @default.
- W2016821035 cites W2024070019 @default.
- W2016821035 cites W2024306318 @default.
- W2016821035 cites W2025716800 @default.
- W2016821035 cites W2029254183 @default.
- W2016821035 cites W2030892254 @default.
- W2016821035 cites W2034669746 @default.
- W2016821035 cites W2044371812 @default.
- W2016821035 cites W2047879681 @default.
- W2016821035 cites W2053265248 @default.
- W2016821035 cites W2055786819 @default.
- W2016821035 cites W2059467528 @default.
- W2016821035 cites W2059913895 @default.
- W2016821035 cites W2060173267 @default.
- W2016821035 cites W2062629127 @default.
- W2016821035 cites W2071548379 @default.
- W2016821035 cites W2075352602 @default.
- W2016821035 cites W2081427260 @default.
- W2016821035 cites W2094334993 @default.
- W2016821035 cites W2097767970 @default.
- W2016821035 cites W2101108802 @default.
- W2016821035 cites W2101178075 @default.
- W2016821035 cites W2104602638 @default.
- W2016821035 cites W2137035181 @default.
- W2016821035 cites W2144701362 @default.
- W2016821035 cites W2152276424 @default.
- W2016821035 cites W2157740207 @default.
- W2016821035 cites W2165447788 @default.
- W2016821035 cites W2167930114 @default.
- W2016821035 doi "https://doi.org/10.1016/j.neuroscience.2007.05.040" @default.
- W2016821035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17629407" @default.
- W2016821035 hasPublicationYear "2007" @default.
- W2016821035 type Work @default.
- W2016821035 sameAs 2016821035 @default.
- W2016821035 citedByCount "66" @default.
- W2016821035 countsByYear W20168210352012 @default.
- W2016821035 countsByYear W20168210352013 @default.
- W2016821035 countsByYear W20168210352014 @default.
- W2016821035 countsByYear W20168210352015 @default.
- W2016821035 countsByYear W20168210352016 @default.
- W2016821035 countsByYear W20168210352017 @default.
- W2016821035 countsByYear W20168210352018 @default.
- W2016821035 countsByYear W20168210352019 @default.
- W2016821035 countsByYear W20168210352020 @default.
- W2016821035 countsByYear W20168210352022 @default.
- W2016821035 countsByYear W20168210352023 @default.
- W2016821035 crossrefType "journal-article" @default.
- W2016821035 hasAuthorship W2016821035A5020212173 @default.
- W2016821035 hasAuthorship W2016821035A5025354885 @default.
- W2016821035 hasAuthorship W2016821035A5036487279 @default.
- W2016821035 hasAuthorship W2016821035A5053088987 @default.
- W2016821035 hasAuthorship W2016821035A5055184036 @default.
- W2016821035 hasAuthorship W2016821035A5062220638 @default.
- W2016821035 hasAuthorship W2016821035A5091324614 @default.
- W2016821035 hasConcept C11960822 @default.
- W2016821035 hasConcept C126322002 @default.
- W2016821035 hasConcept C178666793 @default.
- W2016821035 hasConcept C181912034 @default.
- W2016821035 hasConcept C184235292 @default.
- W2016821035 hasConcept C185592680 @default.
- W2016821035 hasConcept C25498285 @default.
- W2016821035 hasConcept C2777553839 @default.
- W2016821035 hasConcept C2779417574 @default.
- W2016821035 hasConcept C2780610907 @default.
- W2016821035 hasConcept C541997718 @default.
- W2016821035 hasConcept C55493867 @default.
- W2016821035 hasConcept C62478195 @default.
- W2016821035 hasConcept C71924100 @default.
- W2016821035 hasConcept C75217442 @default.
- W2016821035 hasConcept C85528070 @default.
- W2016821035 hasConcept C86554907 @default.