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• W2016826563 abstract "Several studies have suggested that evolving mechanical stresses and strains drive atherosclerotic plaque development and vulnerability. Especially, stress distribution in the plaque fibrous capsule is an important determinant for the risk of vulnerable plaque rupture. Knowledge of the stiffness of atherosclerotic plaque components is therefore of critical importance. In this work, force mapping experiments using atomic force microscopy (AFM) were conducted in apolipoprotein E-deficient (ApoE−/−) mouse, which represents the most widely used experimental model for studying mechanisms underlying the development of atherosclerotic lesions. To obtain the elastic material properties of fibrous caps and lipidic cores of atherosclerotic plaques, serial cross-sections of aortic arch lesions were probed at different sites. Atherosclerotic plaque sub-structures were subdivided into cellular fibrotic, hypocellular fibrotic and lipidic rich areas according to histological staining. Hertz’s contact mechanics were used to determine elasticity (Young’s) moduli that were related to the underlying histological plaque structure. Cellular fibrotic regions exhibit a mean Young modulus of 10.4 ± 5.7 kPa. Hypocellular fibrous caps were almost six-times stiffer, with average modulus value of 59.4 ± 47.4 kPa, locally rising up to ∼250 kPa. Lipid rich areas exhibit a rather large range of Young’s moduli, with average value of 5.5 ± 3.5 kPa. Such precise quantification of plaque stiffness heterogeneity will allow investigators to have prospectively a better monitoring of atherosclerotic disease evolution, including arterial wall remodeling and plaque rupture, in response to mechanical constraints imposed by vascular shear stress and blood pressure." @default.
• W2016826563 created "2016-06-24" @default.
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• W2016826563 date "2011-04-01" @default.
• W2016826563 modified "2023-09-23" @default.
• W2016826563 title "Mapping elasticity moduli of atherosclerotic plaque in situ via atomic force microscopy" @default.
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• W2016826563 doi "https://doi.org/10.1016/j.jsb.2011.01.010" @default.
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