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• W2016827757 endingPage "655" @default.
• W2016827757 startingPage "646" @default.
• W2016827757 abstract "The differentiation of naive CD4+ T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ, whereas Th2 cells express IL-4. The discovery and investigation of two other CD4+ T cell subsets, induced regulatory T (iTreg) cells and Th17 cells, has led to a rethinking of the notion that helper T cell subsets represent irreversibly differentiated endpoints. Accumulating evidence suggests that CD4+ T cells, particularly iTreg and Th17 cells, are more plastic than previously appreciated. It appears that expression of Foxp3 by iTreg cells or IL-17 by Th17 cells may not be stable and that there is a great degree of flexibility in their differentiation options. Here, we will discuss recent findings that demonstrate the plasticity of CD4+ T cell differentiation and the biological implications of this flexibility. The differentiation of naive CD4+ T cells into lineages with distinct effector functions has been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ, whereas Th2 cells express IL-4. The discovery and investigation of two other CD4+ T cell subsets, induced regulatory T (iTreg) cells and Th17 cells, has led to a rethinking of the notion that helper T cell subsets represent irreversibly differentiated endpoints. Accumulating evidence suggests that CD4+ T cells, particularly iTreg and Th17 cells, are more plastic than previously appreciated. It appears that expression of Foxp3 by iTreg cells or IL-17 by Th17 cells may not be stable and that there is a great degree of flexibility in their differentiation options. Here, we will discuss recent findings that demonstrate the plasticity of CD4+ T cell differentiation and the biological implications of this flexibility." @default.
• W2016827757 created "2016-06-24" @default.
• W2016827757 creator A5016829794 @default.
• W2016827757 creator A5042700675 @default.
• W2016827757 creator A5049771268 @default.
• W2016827757 date "2009-05-01" @default.
• W2016827757 modified "2023-10-13" @default.
• W2016827757 title "Plasticity of CD4+ T Cell Lineage Differentiation" @default.
• W2016827757 cites W1575237888 @default.
• W2016827757 cites W1606140593 @default.
• W2016827757 cites W1964465182 @default.
• W2016827757 cites W1966073503 @default.
• W2016827757 cites W1975336035 @default.
• W2016827757 cites W1977836556 @default.
• W2016827757 cites W1979812167 @default.
• W2016827757 cites W1980780108 @default.
• W2016827757 cites W1981008354 @default.
• W2016827757 cites W1982362444 @default.
• W2016827757 cites W1983019708 @default.
• W2016827757 cites W1986370046 @default.
• W2016827757 cites W1987076250 @default.
• W2016827757 cites W1987128447 @default.
• W2016827757 cites W1987628377 @default.
• W2016827757 cites W1988369300 @default.
• W2016827757 cites W1989354231 @default.
• W2016827757 cites W1989694037 @default.
• W2016827757 cites W1996030249 @default.
• W2016827757 cites W1996532235 @default.
• W2016827757 cites W1999561404 @default.
• W2016827757 cites W2001740313 @default.
• W2016827757 cites W2002726823 @default.
• W2016827757 cites W2004774344 @default.
• W2016827757 cites W2011882192 @default.
• W2016827757 cites W2012077729 @default.
• W2016827757 cites W2012097777 @default.
• W2016827757 cites W2013146483 @default.
• W2016827757 cites W2014750930 @default.
• W2016827757 cites W2021603971 @default.
• W2016827757 cites W2025630151 @default.
• W2016827757 cites W2035506432 @default.
• W2016827757 cites W2036383793 @default.
• W2016827757 cites W2037259928 @default.
• W2016827757 cites W2037505364 @default.
• W2016827757 cites W2040080235 @default.
• W2016827757 cites W2042586707 @default.
• W2016827757 cites W2043776488 @default.
• W2016827757 cites W2045763435 @default.
• W2016827757 cites W2051058933 @default.
• W2016827757 cites W2051529467 @default.
• W2016827757 cites W2054344840 @default.
• W2016827757 cites W2065655094 @default.
• W2016827757 cites W2066951766 @default.
• W2016827757 cites W2068230018 @default.
• W2016827757 cites W2068412205 @default.
• W2016827757 cites W2068577743 @default.
• W2016827757 cites W2072417345 @default.
• W2016827757 cites W2072449713 @default.
• W2016827757 cites W2073007458 @default.
• W2016827757 cites W2080935386 @default.
• W2016827757 cites W2082331075 @default.
• W2016827757 cites W2085441977 @default.
• W2016827757 cites W2086264253 @default.
• W2016827757 cites W2090831287 @default.
• W2016827757 cites W2091301099 @default.
• W2016827757 cites W2091451666 @default.
• W2016827757 cites W2092263607 @default.
• W2016827757 cites W2092345398 @default.
• W2016827757 cites W2092975931 @default.
• W2016827757 cites W2097811455 @default.
• W2016827757 cites W2099918076 @default.
• W2016827757 cites W2100357356 @default.
• W2016827757 cites W2101365364 @default.
• W2016827757 cites W2106829739 @default.
• W2016827757 cites W2107235439 @default.
• W2016827757 cites W2107631420 @default.
• W2016827757 cites W2107860814 @default.
• W2016827757 cites W2110957620 @default.
• W2016827757 cites W2111980183 @default.
• W2016827757 cites W2112866067 @default.
• W2016827757 cites W2115785513 @default.
• W2016827757 cites W2120010406 @default.
• W2016827757 cites W2123166427 @default.
• W2016827757 cites W2125503507 @default.
• W2016827757 cites W2128211931 @default.
• W2016827757 cites W2129302556 @default.
• W2016827757 cites W2130486201 @default.
• W2016827757 cites W2135340773 @default.
• W2016827757 cites W2139565733 @default.
• W2016827757 cites W2142017607 @default.
• W2016827757 cites W2142877732 @default.
• W2016827757 cites W2144836936 @default.
• W2016827757 cites W2145152452 @default.
• W2016827757 cites W2145201730 @default.
• W2016827757 cites W2149915530 @default.
• W2016827757 cites W2150505180 @default.
• W2016827757 cites W2153046868 @default.
• W2016827757 cites W2153389047 @default.
• W2016827757 cites W2154728251 @default.

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