FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016831202> ?p ?o ?g. }

• W2016831202 endingPage "2419" @default.
• W2016831202 startingPage "2412" @default.
• W2016831202 abstract "Feline leukemia virus (FeLV) is still a major cause of morbidity and mortality in domestic cats and some wild cats despite the availability of relatively effective vaccines against the virus. FeLV subgroup A (FeLV-A) is transmitted in natural infections, and FeLV subgroups B, C, and T can evolve directly from FeLV-A by mutation and/or recombination with endogenous retroviruses in domestic cats, resulting in a variety of pathogenic outcomes. The cell surface entry receptor for FeLV-A is a putative thiamine transporter (THTR1). Here, we have addressed whether FeLV-A infection might disrupt thiamine uptake into cells and, because thiamine is an essential nutrient, whether this disruption might have pathological consequences. First, we cloned the cat ortholog of the other of the two known thiamine transporters in mammals, THTR2, and we show that feline THTR1 (feTHTR1) and feTHTR2 both mediate thiamine uptake, but feTHTR2 does not function as a receptor for FeLV-A. We found that feTHTR1 is widely expressed in cat tissues and in cell lines, while expression of feTHTR2 is restricted. Thiamine uptake mediated by feTHTR1 was indeed blocked by FeLV-A infection, and in feline fibroblasts that naturally express feTHTR1 and not feTHTR2, this blockade resulted in a growth arrest at physiological concentrations of extracellular thiamine. The growth arrest was reversed at high extracellular concentrations of thiamine. Our results show that FeLV-A infection can indeed disrupt thiamine uptake with pathological consequences. A prediction of these experiments is that raising the plasma levels of thiamine in FeLV-infected cats may ameliorate the pathogenic effects of infection." @default.
• W2016831202 created "2016-06-24" @default.
• W2016831202 creator A5026763137 @default.
• W2016831202 creator A5075328638 @default.
• W2016831202 creator A5085061147 @default.
• W2016831202 date "2013-03-01" @default.
• W2016831202 modified "2023-10-16" @default.
• W2016831202 title "Disruption of Thiamine Uptake and Growth of Cells by Feline Leukemia Virus Subgroup A" @default.
• W2016831202 cites W1512597168 @default.
• W2016831202 cites W1538215925 @default.
• W2016831202 cites W1541422616 @default.
• W2016831202 cites W1601021719 @default.
• W2016831202 cites W1969679162 @default.
• W2016831202 cites W1974451165 @default.
• W2016831202 cites W1979783264 @default.
• W2016831202 cites W1987551215 @default.
• W2016831202 cites W1989394002 @default.
• W2016831202 cites W1997733399 @default.
• W2016831202 cites W1998152325 @default.
• W2016831202 cites W2001041508 @default.
• W2016831202 cites W2004109067 @default.
• W2016831202 cites W2006448792 @default.
• W2016831202 cites W2008512258 @default.
• W2016831202 cites W2025046633 @default.
• W2016831202 cites W2029313692 @default.
• W2016831202 cites W2033198883 @default.
• W2016831202 cites W2044307925 @default.
• W2016831202 cites W2055145487 @default.
• W2016831202 cites W2057688982 @default.
• W2016831202 cites W2067923512 @default.
• W2016831202 cites W2070600008 @default.
• W2016831202 cites W2071812481 @default.
• W2016831202 cites W2080134256 @default.
• W2016831202 cites W2093558312 @default.
• W2016831202 cites W2097252258 @default.
• W2016831202 cites W2102742825 @default.
• W2016831202 cites W2107242273 @default.
• W2016831202 cites W2112092468 @default.
• W2016831202 cites W2118469386 @default.
• W2016831202 cites W2121270588 @default.
• W2016831202 cites W2123690375 @default.
• W2016831202 cites W2124407453 @default.
• W2016831202 cites W2131963200 @default.
• W2016831202 cites W2132492733 @default.
• W2016831202 cites W2132632499 @default.
• W2016831202 cites W2136280576 @default.
• W2016831202 cites W2162020175 @default.
• W2016831202 cites W2163222909 @default.
• W2016831202 cites W2167844976 @default.
• W2016831202 cites W4243432010 @default.
• W2016831202 doi "https://doi.org/10.1128/jvi.03203-12" @default.
• W2016831202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3571393" @default.
• W2016831202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23269813" @default.
• W2016831202 hasPublicationYear "2013" @default.
• W2016831202 type Work @default.
• W2016831202 sameAs 2016831202 @default.
• W2016831202 citedByCount "12" @default.
• W2016831202 countsByYear W20168312022013 @default.
• W2016831202 countsByYear W20168312022016 @default.
• W2016831202 countsByYear W20168312022017 @default.
• W2016831202 countsByYear W20168312022019 @default.
• W2016831202 countsByYear W20168312022021 @default.
• W2016831202 countsByYear W20168312022022 @default.
• W2016831202 countsByYear W20168312022023 @default.
• W2016831202 crossrefType "journal-article" @default.
• W2016831202 hasAuthorship W2016831202A5026763137 @default.
• W2016831202 hasAuthorship W2016831202A5075328638 @default.
• W2016831202 hasAuthorship W2016831202A5085061147 @default.
• W2016831202 hasBestOaLocation W20168312021 @default.
• W2016831202 hasConcept C126322002 @default.
• W2016831202 hasConcept C159047783 @default.
• W2016831202 hasConcept C203014093 @default.
• W2016831202 hasConcept C2522874641 @default.
• W2016831202 hasConcept C2776203871 @default.
• W2016831202 hasConcept C2778431562 @default.
• W2016831202 hasConcept C2779692357 @default.
• W2016831202 hasConcept C2779904517 @default.
• W2016831202 hasConcept C28406088 @default.
• W2016831202 hasConcept C54355233 @default.
• W2016831202 hasConcept C55493867 @default.
• W2016831202 hasConcept C71924100 @default.
• W2016831202 hasConcept C81885089 @default.
• W2016831202 hasConcept C86803240 @default.
• W2016831202 hasConcept C95444343 @default.
• W2016831202 hasConceptScore W2016831202C126322002 @default.
• W2016831202 hasConceptScore W2016831202C159047783 @default.
• W2016831202 hasConceptScore W2016831202C203014093 @default.
• W2016831202 hasConceptScore W2016831202C2522874641 @default.
• W2016831202 hasConceptScore W2016831202C2776203871 @default.
• W2016831202 hasConceptScore W2016831202C2778431562 @default.
• W2016831202 hasConceptScore W2016831202C2779692357 @default.
• W2016831202 hasConceptScore W2016831202C2779904517 @default.
• W2016831202 hasConceptScore W2016831202C28406088 @default.
• W2016831202 hasConceptScore W2016831202C54355233 @default.
• W2016831202 hasConceptScore W2016831202C55493867 @default.
• W2016831202 hasConceptScore W2016831202C71924100 @default.
• W2016831202 hasConceptScore W2016831202C81885089 @default.
• W2016831202 hasConceptScore W2016831202C86803240 @default.

• next