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- W2016849481 abstract "Downregulation of KAI1 metastasis suppressor protein is associated with dismal prognosis in a variety of cancers. Mutation of p53 was suggested to be involved in KAI1-downregulation. In cervical cancer, p53 is inactivated by human papillomavirus (HPV) oncoprotein E6 with the grade of inactivation depending on the HPV type. KAI1-expression was immunohistochemically determined in 67 specimens of cervical cancer, HPV-typing was performed using polymerase chain reaction (PCR), cloning, and sequencing. KAI1-downregulation was found in 68.1% of patients, HPV-infection in 91%. There was no association of KAI1-downregulation and infection with a particular HPV type. KAI1-downregulation in cervical cancer seems independent of HPV-E6 induced p53 inactivation." @default.
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- W2016849481 date "2001-01-26" @default.
- W2016849481 modified "2023-09-27" @default.
- W2016849481 title "Impact of human papillomavirus infection on the expression of the KAI1 metastasis suppressor protein in invasive cervical cancer." @default.
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- W2016849481 doi "https://doi.org/10.1016/s0304-3835(00)00672-8" @default.
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