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- W2016852521 abstract "IN 1987, 24 BRAZILIAN dialysis and kidney transplant centers in the state of Sao Paulo, located in 17 cities, joined efforts to participate in a single society named Sao Paulo Interior Transplant (SPIT). The main objective of SPIT is the allocation of cadaver kidneys according to HLA matching. Accordingly, all recipient candidates and cadaver donors were typed for HLA antigens in the city of Ribeirao Preto, and the allocation, scheme used the criteria proposed by The United Network for Organ Sharing (UNOS). Since its foundation, SPIT has performed over 1000 kidney transplants. The Brazilian population was formed by the contribution of genes of individuals from several ethnic backgrounds, including Caucasian immigrants from many regions of Europe, African American individuals predominantly from the Niger-Congo area of Equatorial Africa, and native Amerindian populations. DNA typing of HLA alleles for kidney transplantation has been considered to be much more accurate than serologic identification, leading to an increased allograft survival, according to the data published by several large multicenter studies. Since the Brazilian population is genetically highly diverse and since HLA molecular typing has been correlated with better allograft survival, all kidney recipients on the waiting list of SPIT were retyped for HLA-DRB1 alleles by DNA technology using sequence-specific primers (PCR-SSP) in polymerase chain reactions. In this study, we compared the results of previous HLA-DR typing using conventional serology with HLA-DRB1 typing using the PCR-SSP technique." @default.
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- W2016852521 date "2002-03-01" @default.
- W2016852521 modified "2023-10-16" @default.
- W2016852521 title "Comparative study of HLA-DR typing by serology and sequence-specific primer analysis in a genetically highly diverse population of kidney transplant recipients" @default.
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- W2016852521 doi "https://doi.org/10.1016/s0041-1345(02)02596-4" @default.
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