FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016855276> ?p ?o ?g. }

• W2016855276 endingPage "1162" @default.
• W2016855276 startingPage "1149" @default.
• W2016855276 abstract "Transient receptor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-threonine kinase domain. Here, we find that Trpm7-/- T cells are deficient in Fas-receptor-induced apoptosis and that TRPM7 channel activity participates in the apoptotic process and is regulated by caspase-dependent cleavage. This function of TRPM7 is dependent on its function as a channel, but not as a kinase. TRPM7 is cleaved by caspases at D1510, disassociating the carboxy-terminal kinase domain from the pore without disrupting the phosphotransferase activity of the released kinase but substantially increasing TRPM7 ion channel activity. Furthermore, we show that TRPM7 regulates endocytic compartmentalization of the Fas receptor after receptor stimulation, an important process for apoptotic signaling through Fas receptors. These findings raise the possibility that other members of the TRP channel superfamily are also regulated by caspase-mediated cleavage, with wide-ranging implications for cell death and differentiation." @default.
• W2016855276 created "2016-06-24" @default.
• W2016855276 creator A5005353453 @default.
• W2016855276 creator A5014336145 @default.
• W2016855276 creator A5028751463 @default.
• W2016855276 creator A5037718871 @default.
• W2016855276 creator A5040902469 @default.
• W2016855276 creator A5050422161 @default.
• W2016855276 creator A5056525752 @default.
• W2016855276 creator A5064145098 @default.
• W2016855276 creator A5070638619 @default.
• W2016855276 creator A5070661554 @default.
• W2016855276 creator A5086029003 @default.
• W2016855276 date "2012-06-01" @default.
• W2016855276 modified "2023-10-06" @default.
• W2016855276 title "Cleavage of TRPM7 Releases the Kinase Domain from the Ion Channel and Regulates Its Participation in Fas-Induced Apoptosis" @default.
• W2016855276 cites W1542758544 @default.
• W2016855276 cites W1559892880 @default.
• W2016855276 cites W1567917794 @default.
• W2016855276 cites W1964159573 @default.
• W2016855276 cites W1968006149 @default.
• W2016855276 cites W1971016926 @default.
• W2016855276 cites W1975593978 @default.
• W2016855276 cites W1976111921 @default.
• W2016855276 cites W1979319210 @default.
• W2016855276 cites W1983476428 @default.
• W2016855276 cites W1986331996 @default.
• W2016855276 cites W1987396009 @default.
• W2016855276 cites W1997808089 @default.
• W2016855276 cites W2018442465 @default.
• W2016855276 cites W2022645001 @default.
• W2016855276 cites W2028111124 @default.
• W2016855276 cites W2029265742 @default.
• W2016855276 cites W2030001189 @default.
• W2016855276 cites W2033290380 @default.
• W2016855276 cites W2041191931 @default.
• W2016855276 cites W2042577315 @default.
• W2016855276 cites W2051972593 @default.
• W2016855276 cites W2062853648 @default.
• W2016855276 cites W2065518020 @default.
• W2016855276 cites W2066581734 @default.
• W2016855276 cites W2072799789 @default.
• W2016855276 cites W2075715972 @default.
• W2016855276 cites W2081286585 @default.
• W2016855276 cites W2083533003 @default.
• W2016855276 cites W2085926680 @default.
• W2016855276 cites W2087668761 @default.
• W2016855276 cites W2088511948 @default.
• W2016855276 cites W2099776872 @default.
• W2016855276 cites W2105198579 @default.
• W2016855276 cites W2110827218 @default.
• W2016855276 cites W2114610934 @default.
• W2016855276 cites W2117062067 @default.
• W2016855276 cites W2119683782 @default.
• W2016855276 cites W2127012396 @default.
• W2016855276 cites W2133958296 @default.
• W2016855276 cites W2134706781 @default.
• W2016855276 cites W2145611701 @default.
• W2016855276 cites W2146828787 @default.
• W2016855276 cites W2149924710 @default.
• W2016855276 cites W2149967205 @default.
• W2016855276 cites W2151200090 @default.
• W2016855276 cites W2156783552 @default.
• W2016855276 cites W2166073081 @default.
• W2016855276 cites W2167318614 @default.
• W2016855276 cites W2171339002 @default.
• W2016855276 cites W2402045319 @default.
• W2016855276 doi "https://doi.org/10.1016/j.devcel.2012.04.006" @default.
• W2016855276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3397829" @default.
• W2016855276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22698280" @default.
• W2016855276 hasPublicationYear "2012" @default.
• W2016855276 type Work @default.
• W2016855276 sameAs 2016855276 @default.
• W2016855276 citedByCount "124" @default.
• W2016855276 countsByYear W20168552762012 @default.
• W2016855276 countsByYear W20168552762013 @default.
• W2016855276 countsByYear W20168552762014 @default.
• W2016855276 countsByYear W20168552762015 @default.
• W2016855276 countsByYear W20168552762016 @default.
• W2016855276 countsByYear W20168552762017 @default.
• W2016855276 countsByYear W20168552762018 @default.
• W2016855276 countsByYear W20168552762019 @default.
• W2016855276 countsByYear W20168552762020 @default.
• W2016855276 countsByYear W20168552762021 @default.
• W2016855276 countsByYear W20168552762022 @default.
• W2016855276 countsByYear W20168552762023 @default.
• W2016855276 crossrefType "journal-article" @default.
• W2016855276 hasAuthorship W2016855276A5005353453 @default.
• W2016855276 hasAuthorship W2016855276A5014336145 @default.
• W2016855276 hasAuthorship W2016855276A5028751463 @default.
• W2016855276 hasAuthorship W2016855276A5037718871 @default.
• W2016855276 hasAuthorship W2016855276A5040902469 @default.
• W2016855276 hasAuthorship W2016855276A5050422161 @default.
• W2016855276 hasAuthorship W2016855276A5056525752 @default.
• W2016855276 hasAuthorship W2016855276A5064145098 @default.
• W2016855276 hasAuthorship W2016855276A5070638619 @default.
• W2016855276 hasAuthorship W2016855276A5070661554 @default.
• W2016855276 hasAuthorship W2016855276A5086029003 @default.

• next