Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016857777> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2016857777 abstract "Results: All animals exhibited a more painful joint on day 3 postinjection compared to day 0 (Fig. 1). Higher MIA dose caused more pain and greater gait alteration than the lower dose after day 7 with one exception. There was no difference on weight distribution between the two doses on day 35. Animals injected with 2mg MIA had larger knee diameter than those with 0.5mg MIA. Bone volume (Fig. 2) was significantly lower in animals injected with high dose of MIA. However, bone volume in both groups increased from day 21 to day 35 regardless of MIA dose. The high MIA dose caused significantly more severe cartilage matrix damage (Fig. 3), bone resorption and osteophyte formation on day 21, which did not worsen further by day 35. In the low MIA injection group, severity of joint damage increased from day 21 to day 35, resulting in similar levels of damage for both groups by day 35. The subchondral bone sclerosis was worse in lower dose group than the higher one on both days. Conclusions: In this study, we evaluated the temporal effect of MIA dose on joint pain and structural damages using an established rat model. The results demonstrated that the higher MIA dose caused more severe joint swelling, pain, and histopathologic alterations than the lower dose. It was observed that both standing and moving pain recovered over time for both groups over 35 days while the joint structures continued their deterioration. Most surprisingly, the standing pain was almost completely alleviated by day 35 while the joints exhibited a strikingly severe degeneration. To our knowledge, this is the first report of such temporally differential changes on pain and structural damage in MIA induced rodent model. The results will shed light on the application of rat MIA model in evaluating biologics and pharmaceuticals for OA treatment." @default.
- W2016857777 created "2016-06-24" @default.
- W2016857777 creator A5001355296 @default.
- W2016857777 creator A5012051319 @default.
- W2016857777 creator A5025282648 @default.
- W2016857777 creator A5047175684 @default.
- W2016857777 creator A5059577879 @default.
- W2016857777 creator A5072004003 @default.
- W2016857777 creator A5073331119 @default.
- W2016857777 creator A5074723025 @default.
- W2016857777 date "2011-09-01" @default.
- W2016857777 modified "2023-09-27" @default.
- W2016857777 title "130 INFRAPATELLAR FAT PAD HYPERTROPHY WITHOUT INFLAMMATION IN A DIET-INDUCED MOUSE MODEL OF OBESHY AND OSTEOARTHRITIS" @default.
- W2016857777 doi "https://doi.org/10.1016/s1063-4584(11)60157-x" @default.
- W2016857777 hasPublicationYear "2011" @default.
- W2016857777 type Work @default.
- W2016857777 sameAs 2016857777 @default.
- W2016857777 citedByCount "5" @default.
- W2016857777 countsByYear W20168577772014 @default.
- W2016857777 countsByYear W20168577772016 @default.
- W2016857777 countsByYear W20168577772017 @default.
- W2016857777 countsByYear W20168577772019 @default.
- W2016857777 crossrefType "journal-article" @default.
- W2016857777 hasAuthorship W2016857777A5001355296 @default.
- W2016857777 hasAuthorship W2016857777A5012051319 @default.
- W2016857777 hasAuthorship W2016857777A5025282648 @default.
- W2016857777 hasAuthorship W2016857777A5047175684 @default.
- W2016857777 hasAuthorship W2016857777A5059577879 @default.
- W2016857777 hasAuthorship W2016857777A5072004003 @default.
- W2016857777 hasAuthorship W2016857777A5073331119 @default.
- W2016857777 hasAuthorship W2016857777A5074723025 @default.
- W2016857777 hasBestOaLocation W20168577771 @default.
- W2016857777 hasConcept C126322002 @default.
- W2016857777 hasConcept C142724271 @default.
- W2016857777 hasConcept C167414201 @default.
- W2016857777 hasConcept C204787440 @default.
- W2016857777 hasConcept C2776164576 @default.
- W2016857777 hasConcept C2776237595 @default.
- W2016857777 hasConcept C2776610510 @default.
- W2016857777 hasConcept C2776914184 @default.
- W2016857777 hasConcept C71924100 @default.
- W2016857777 hasConceptScore W2016857777C126322002 @default.
- W2016857777 hasConceptScore W2016857777C142724271 @default.
- W2016857777 hasConceptScore W2016857777C167414201 @default.
- W2016857777 hasConceptScore W2016857777C204787440 @default.
- W2016857777 hasConceptScore W2016857777C2776164576 @default.
- W2016857777 hasConceptScore W2016857777C2776237595 @default.
- W2016857777 hasConceptScore W2016857777C2776610510 @default.
- W2016857777 hasConceptScore W2016857777C2776914184 @default.
- W2016857777 hasConceptScore W2016857777C71924100 @default.
- W2016857777 hasLocation W20168577771 @default.
- W2016857777 hasOpenAccess W2016857777 @default.
- W2016857777 hasPrimaryLocation W20168577771 @default.
- W2016857777 hasRelatedWork W1990895739 @default.
- W2016857777 hasRelatedWork W1998266256 @default.
- W2016857777 hasRelatedWork W2012995682 @default.
- W2016857777 hasRelatedWork W2041609594 @default.
- W2016857777 hasRelatedWork W2044008984 @default.
- W2016857777 hasRelatedWork W2055582825 @default.
- W2016857777 hasRelatedWork W2062625915 @default.
- W2016857777 hasRelatedWork W2151259395 @default.
- W2016857777 hasRelatedWork W2188596811 @default.
- W2016857777 hasRelatedWork W2318628952 @default.
- W2016857777 hasRelatedWork W2323302346 @default.
- W2016857777 hasRelatedWork W2334264989 @default.
- W2016857777 hasRelatedWork W2407724939 @default.
- W2016857777 hasRelatedWork W2464342507 @default.
- W2016857777 hasRelatedWork W2597632299 @default.
- W2016857777 hasRelatedWork W2756159746 @default.
- W2016857777 hasRelatedWork W3012910233 @default.
- W2016857777 hasRelatedWork W3082260455 @default.
- W2016857777 hasRelatedWork W3113562803 @default.
- W2016857777 hasRelatedWork W3130020109 @default.
- W2016857777 isParatext "false" @default.
- W2016857777 isRetracted "false" @default.
- W2016857777 magId "2016857777" @default.
- W2016857777 workType "article" @default.