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- W2016861487 abstract "Infusion of Ring-A-reduced metabolites of aldosterone in adrenalectomized male rats for 4 days revealed that 5α-Ring-A-reduced derivatives, 5α-dihydroaldosterone (5α-DHAldo; 2.5–5.0 μg/day), 3α,5α-tetrahydroaldosterone (3α,5α-THAldo; 5–25 μg/day), and 3β,5α-THAldo (50–175 μg/day) possessed intrinsic Na+-retaining activity. The same infusions of 5α-DHAldo, 3α,5α-THAldo, and 3β,5α-THAldo, also lowered the urinary excretion of potassium. The 5β-Ring-A-reduced derivative 3α,5β-THALdo did not demonstrate either of these biological properties. In another set of experiments, on the fourth day of infusion, aldosterone (0.1 μg/rat) was administered acutely subcutaneously; none of the Ring-A-reduced derivatives altered the Na+-retaining activity of aldosterone. However, in a dose-dependent manner, both 3α,5α-THAldo and 3β,5α-THAldo blunted the urinary K+-secretory effect of aldosterone; low dosages of 5α-DHAldo and larger dosages of 3α,5β-THAldo did not. Thus, the 5α-reduced derivatives of aldosterone not only lowered urinary Na+ and K+ excretion in their own right, but two of them blunted the kaliuretic response of the parent mineralocorticoid, aldosterone. Further experiments will be required to determine whether these aldosterone metabolites are further metabolized or interconverted during the expression of the regulatory properties described here and whether these properties are physiologically relevant." @default.
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- W2016861487 title "The effects of infusions of ring-a-reduced derivatives of aldosterone on the antinatriuretic and kaliuretic actions of aldosterone" @default.
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- W2016861487 doi "https://doi.org/10.1016/0039-128x(89)90143-8" @default.
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