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- W2016874554 abstract "Central pain (CP) remains difficult to treat in spite of recent advances.1 Topiramate, a novel antiepileptic agent, has been reported to be effective for intercostal, MS-associated, and idiopathic trigeminal neuralgia and sundry peripheral neuropathic pain conditions in some but not all open-label case series (e.g., see Gilron et al.2).There are no studies on the use of topiramate for CP. We report no effect in this prospective open-label study of seven patients with refractory CP.Seven consecutive patients with CP of both brain and spinal cord origin were evaluated (three men, four women; mean age: 59.4 years; range: 48 to 73 years). Mean duration of CP was 5.8 years (range 3 to 13 years). In all cases, CP was described as a constant burning dysesthetic pain with thermal or mechanical allodynia in appropriate bodily areas.Pain was due to …" @default.
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- W2016874554 date "2002-03-12" @default.
- W2016874554 modified "2023-09-24" @default.
- W2016874554 title "Lack of effect of topiramate for central pain" @default.
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- W2016874554 doi "https://doi.org/10.1212/wnl.58.5.831-a" @default.
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