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• W2016880441 abstract "Summary: Purpose:To determine whether focal cortical dysplasia alters excitability in regions distant to the region of the dysplasia. Methods; We studied the physiological consequences of cortical dysplasia induced by either m e or three freeze lesions at birth. Seizure susceptibility was assessed at age 35 days by unygdala kindling. C-fos immunoataining was performed after kainic acid-induced seizures at 10. 20, or 30 days to evaluate the patterns of neuronal activation. Results: Freeze lesions consistently produced uniform regions of dysplasia. No significant differences in seizure susceptibility, as measured by afterdischarge threshold and kindling rate. were seen between controls and rats receiving either one or three freeze lesions. C-fos activation after kainic acid injection was not observed in the region of the dysplasia. However, rats with freeze lesions at age 30 days dcinonstrated asymmetric c-fos staining with greater staining in CAI ipsilateral. than contralateral, to the lesion. Conclusions: Focal cortical dysplasia resuIts in enhnncemen of c-fos activation in regions outside the borders of the dysplasia. However, as indicated by kindling rate. the functional con sequences of these alterations do not appear to be robust." @default.
• W2016880441 created "2016-06-24" @default.
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• W2016880441 date "1999-05-01" @default.
• W2016880441 modified "2023-10-11" @default.
• W2016880441 title "Consequences of Cortical Dysplasia During Development in Rats" @default.
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• W2016880441 doi "https://doi.org/10.1111/j.1528-1157.1999.tb05554.x" @default.
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