FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016884806> ?p ?o ?g. }

• W2016884806 endingPage "281" @default.
• W2016884806 startingPage "276" @default.
• W2016884806 abstract "The large variability (7% to 100%) in previously reported rates of receptor tyrosine kinase KIT expression in Merkel cell carcinoma (MCC) may be owing to the use of heat-induced epitope retrieval. High frequency of reported KIT reactivity by immunohistochemistry (IHC) in part prompted the initiation of a phase 2 clinical trial of imatinib mesylate (Gleevec, Novartis Pharmaceuticals, East Hanover, NJ) for the treatment of advanced MCC. Our experience has been that a small number of MCCs (12.5%) are positive for KIT by IHC. We also found a higher rate of apparently KIT-positive MCCs (75%) using heat-induced epitope retrieval. Our anecdotal experience with the use of imatinib mesylate has been disappointing. As IHC detection of KIT expression does not correlate with the presence of KIT-activating mutations, protein expression as tested by IHC should not be used to determine if patients would respond to imatinib mesylate. Indeed, our review of the literature and the apparent lack of efficacy of imatinib mesylate for MCC in a recent phase 2 trial suggest a minor role for KIT signaling in MCC tumorigenesis." @default.
• W2016884806 created "2016-06-24" @default.
• W2016884806 creator A5016782097 @default.
• W2016884806 creator A5018729634 @default.
• W2016884806 creator A5079599874 @default.
• W2016884806 creator A5086507193 @default.
• W2016884806 date "2009-07-01" @default.
• W2016884806 modified "2023-10-10" @default.
• W2016884806 title "Merkel Cell Carcinoma" @default.
• W2016884806 cites W1970096881 @default.
• W2016884806 cites W1974789369 @default.
• W2016884806 cites W1974957798 @default.
• W2016884806 cites W1996795281 @default.
• W2016884806 cites W1997033989 @default.
• W2016884806 cites W2000409373 @default.
• W2016884806 cites W2009358750 @default.
• W2016884806 cites W2011322082 @default.
• W2016884806 cites W2014300063 @default.
• W2016884806 cites W2014827370 @default.
• W2016884806 cites W2026576341 @default.
• W2016884806 cites W2032535154 @default.
• W2016884806 cites W2033128496 @default.
• W2016884806 cites W2041415161 @default.
• W2016884806 cites W2045790741 @default.
• W2016884806 cites W2053314612 @default.
• W2016884806 cites W2055648133 @default.
• W2016884806 cites W2074608272 @default.
• W2016884806 cites W2075661245 @default.
• W2016884806 cites W2085480841 @default.
• W2016884806 cites W2085894543 @default.
• W2016884806 cites W2092557163 @default.
• W2016884806 cites W2106742435 @default.
• W2016884806 cites W2113589296 @default.
• W2016884806 cites W2113844763 @default.
• W2016884806 cites W2119455657 @default.
• W2016884806 cites W2138647235 @default.
• W2016884806 cites W2142858515 @default.
• W2016884806 cites W2145965676 @default.
• W2016884806 cites W2150501295 @default.
• W2016884806 cites W2159154806 @default.
• W2016884806 cites W2238543902 @default.
• W2016884806 cites W2316574821 @default.
• W2016884806 cites W2317628677 @default.
• W2016884806 doi "https://doi.org/10.1097/pai.0b013e318194da49" @default.
• W2016884806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19276970" @default.
• W2016884806 hasPublicationYear "2009" @default.
• W2016884806 type Work @default.
• W2016884806 sameAs 2016884806 @default.
• W2016884806 citedByCount "9" @default.
• W2016884806 countsByYear W20168848062012 @default.
• W2016884806 countsByYear W20168848062013 @default.
• W2016884806 countsByYear W20168848062015 @default.
• W2016884806 crossrefType "journal-article" @default.
• W2016884806 hasAuthorship W2016884806A5016782097 @default.
• W2016884806 hasAuthorship W2016884806A5018729634 @default.
• W2016884806 hasAuthorship W2016884806A5079599874 @default.
• W2016884806 hasAuthorship W2016884806A5086507193 @default.
• W2016884806 hasConcept C101544691 @default.
• W2016884806 hasConcept C121608353 @default.
• W2016884806 hasConcept C126322002 @default.
• W2016884806 hasConcept C143998085 @default.
• W2016884806 hasConcept C170493617 @default.
• W2016884806 hasConcept C178790620 @default.
• W2016884806 hasConcept C185592680 @default.
• W2016884806 hasConcept C204232928 @default.
• W2016884806 hasConcept C2777546739 @default.
• W2016884806 hasConcept C2777583451 @default.
• W2016884806 hasConcept C2778342957 @default.
• W2016884806 hasConcept C2778729363 @default.
• W2016884806 hasConcept C2778820342 @default.
• W2016884806 hasConcept C2780194963 @default.
• W2016884806 hasConcept C3019892230 @default.
• W2016884806 hasConcept C42362537 @default.
• W2016884806 hasConcept C502942594 @default.
• W2016884806 hasConcept C71924100 @default.
• W2016884806 hasConceptScore W2016884806C101544691 @default.
• W2016884806 hasConceptScore W2016884806C121608353 @default.
• W2016884806 hasConceptScore W2016884806C126322002 @default.
• W2016884806 hasConceptScore W2016884806C143998085 @default.
• W2016884806 hasConceptScore W2016884806C170493617 @default.
• W2016884806 hasConceptScore W2016884806C178790620 @default.
• W2016884806 hasConceptScore W2016884806C185592680 @default.
• W2016884806 hasConceptScore W2016884806C204232928 @default.
• W2016884806 hasConceptScore W2016884806C2777546739 @default.
• W2016884806 hasConceptScore W2016884806C2777583451 @default.
• W2016884806 hasConceptScore W2016884806C2778342957 @default.
• W2016884806 hasConceptScore W2016884806C2778729363 @default.
• W2016884806 hasConceptScore W2016884806C2778820342 @default.
• W2016884806 hasConceptScore W2016884806C2780194963 @default.
• W2016884806 hasConceptScore W2016884806C3019892230 @default.
• W2016884806 hasConceptScore W2016884806C42362537 @default.
• W2016884806 hasConceptScore W2016884806C502942594 @default.
• W2016884806 hasConceptScore W2016884806C71924100 @default.
• W2016884806 hasIssue "4" @default.
• W2016884806 hasLocation W20168848061 @default.
• W2016884806 hasLocation W20168848062 @default.
• W2016884806 hasOpenAccess W2016884806 @default.
• W2016884806 hasPrimaryLocation W20168848061 @default.

• next