Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016885004> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2016885004 abstract "A novel 44-kDa gene product (D123) has been proposed as necessary for S-phase entry of the cell cycle: a point mutation resulted in a temperature-sensitive arrest in G1-phase. From human fibrosarcoma cDNA library, we have isolated an identical gene and studied its sequence and mRNA and protein expression. Compared with D123, three nucleotide differences within the human coding sequence, plus others, result in a change of two amino acids. A partial sequence similarity has been found with a yeast gene of unknown function. The protein has several potential phosphorylation sites, is highly hydrophilic, and may be highly structured in alpha-helix. The mRNA is abundantly expressed by a variety of normal and transformed cells and by all tissues examined, being most highly expressed in testis. Specific antibodies, raised against a rhD123 polypeptide, recognize a major 42- to 44-kDa molecule in crude extract of various human cell lines. Immunohistochemistry reveals that D123 protein is not homogeneously expressed: it is detected, often in granular vescicles, in the cytoplasm of some epithelial, stromal, and sperm cells and in varicosities lining nervous fibers, while it appears to be absent in nuclei, endothelial, and smooth muscle cells. The precise link between cytoplasmic occurrence of D123 and cell cycle progression still remains to be clarified." @default.
- W2016885004 created "2016-06-24" @default.
- W2016885004 creator A5000037947 @default.
- W2016885004 creator A5007831274 @default.
- W2016885004 creator A5020440344 @default.
- W2016885004 creator A5021059428 @default.
- W2016885004 creator A5036951000 @default.
- W2016885004 creator A5043293851 @default.
- W2016885004 creator A5071537293 @default.
- W2016885004 creator A5087662736 @default.
- W2016885004 date "1998-08-01" @default.
- W2016885004 modified "2023-09-26" @default.
- W2016885004 title "Expression Study on D123 Gene Product: Evidence for High Positivity in Testis" @default.
- W2016885004 cites W1975304761 @default.
- W2016885004 cites W2008399824 @default.
- W2016885004 cites W2010191388 @default.
- W2016885004 cites W2014669590 @default.
- W2016885004 cites W2015292449 @default.
- W2016885004 cites W2019684813 @default.
- W2016885004 cites W2055043387 @default.
- W2016885004 cites W2087064593 @default.
- W2016885004 cites W2091239909 @default.
- W2016885004 cites W2095450147 @default.
- W2016885004 cites W2099254366 @default.
- W2016885004 cites W2111146201 @default.
- W2016885004 cites W2138270253 @default.
- W2016885004 cites W2151525547 @default.
- W2016885004 cites W267927007 @default.
- W2016885004 cites W2915190566 @default.
- W2016885004 cites W3145974153 @default.
- W2016885004 doi "https://doi.org/10.1006/excr.1998.4074" @default.
- W2016885004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9683532" @default.
- W2016885004 hasPublicationYear "1998" @default.
- W2016885004 type Work @default.
- W2016885004 sameAs 2016885004 @default.
- W2016885004 citedByCount "3" @default.
- W2016885004 crossrefType "journal-article" @default.
- W2016885004 hasAuthorship W2016885004A5000037947 @default.
- W2016885004 hasAuthorship W2016885004A5007831274 @default.
- W2016885004 hasAuthorship W2016885004A5020440344 @default.
- W2016885004 hasAuthorship W2016885004A5021059428 @default.
- W2016885004 hasAuthorship W2016885004A5036951000 @default.
- W2016885004 hasAuthorship W2016885004A5043293851 @default.
- W2016885004 hasAuthorship W2016885004A5071537293 @default.
- W2016885004 hasAuthorship W2016885004A5087662736 @default.
- W2016885004 hasConcept C104317684 @default.
- W2016885004 hasConcept C105580179 @default.
- W2016885004 hasConcept C150194340 @default.
- W2016885004 hasConcept C153911025 @default.
- W2016885004 hasConcept C167625842 @default.
- W2016885004 hasConcept C187882448 @default.
- W2016885004 hasConcept C189482833 @default.
- W2016885004 hasConcept C190062978 @default.
- W2016885004 hasConcept C195286587 @default.
- W2016885004 hasConcept C29537977 @default.
- W2016885004 hasConcept C54355233 @default.
- W2016885004 hasConcept C86803240 @default.
- W2016885004 hasConcept C95444343 @default.
- W2016885004 hasConceptScore W2016885004C104317684 @default.
- W2016885004 hasConceptScore W2016885004C105580179 @default.
- W2016885004 hasConceptScore W2016885004C150194340 @default.
- W2016885004 hasConceptScore W2016885004C153911025 @default.
- W2016885004 hasConceptScore W2016885004C167625842 @default.
- W2016885004 hasConceptScore W2016885004C187882448 @default.
- W2016885004 hasConceptScore W2016885004C189482833 @default.
- W2016885004 hasConceptScore W2016885004C190062978 @default.
- W2016885004 hasConceptScore W2016885004C195286587 @default.
- W2016885004 hasConceptScore W2016885004C29537977 @default.
- W2016885004 hasConceptScore W2016885004C54355233 @default.
- W2016885004 hasConceptScore W2016885004C86803240 @default.
- W2016885004 hasConceptScore W2016885004C95444343 @default.
- W2016885004 hasLocation W20168850041 @default.
- W2016885004 hasLocation W20168850042 @default.
- W2016885004 hasOpenAccess W2016885004 @default.
- W2016885004 hasPrimaryLocation W20168850041 @default.
- W2016885004 hasRelatedWork W1485442945 @default.
- W2016885004 hasRelatedWork W1572103384 @default.
- W2016885004 hasRelatedWork W1580533398 @default.
- W2016885004 hasRelatedWork W1586898557 @default.
- W2016885004 hasRelatedWork W2035178353 @default.
- W2016885004 hasRelatedWork W2042804712 @default.
- W2016885004 hasRelatedWork W2081332932 @default.
- W2016885004 hasRelatedWork W21319276 @default.
- W2016885004 hasRelatedWork W2139377393 @default.
- W2016885004 hasRelatedWork W2142848209 @default.
- W2016885004 isParatext "false" @default.
- W2016885004 isRetracted "false" @default.
- W2016885004 magId "2016885004" @default.
- W2016885004 workType "article" @default.