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• W2016902240 abstract "Various amphiphilic heterodinucleoside phosphates have recently been synthesized in order to overcome drug resistance. These agents contain 5-fluorodeoxyuridine (5-FdUrd) and arabinofuranosylcytosine (Ara-C). We now investigated the action of two of these novel dimers (#2 and #10) in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. The dimers were compared with 5-FdUrd and Ara-C for growth inhibition, apoptosis induction, and cell-cycle effects. No significant difference in the cytotoxicity of dimer #2 could be observed between sensitive and 5-FdUrd/Ara-C cross-resistant H9 cells (IC50 values of 220 nM and 200 nM, respectively), indicating that further studies with this compound are warranted." @default.
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• W2016902240 date "2005-07-01" @default.
• W2016902240 modified "2023-09-26" @default.
• W2016902240 title "Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells" @default.
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• W2016902240 doi "https://doi.org/10.1016/j.leukres.2004.12.015" @default.
• W2016902240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15927674" @default.
• W2016902240 hasPublicationYear "2005" @default.
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