Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016906427> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2016906427 endingPage "218" @default.
- W2016906427 startingPage "213" @default.
- W2016906427 abstract "We investigated the efficacy of histidine on iron (II)-induced hydroxyl radical ( .OH) generation in extracellular fluid of the rat myocardium using a flexibly mounted microdialysis technique (O system). Rats were anesthetized and a microdialysis probe was implanted in the left ventricular, followed by infusion of sodium salicylate in Ringer's solution (0.5 nmol/μL/min) to detect the generation .OH as reflected by the non-enzymatic formation of 2,3-dihydroxybenzoic acid (DHBA). Iron (II) clearly produced a concentration-dependent increase in .OH formation. A positive linear correlation between iron (II) and the formation of 2,3-DHBA (R2 = 0.987) was observed. However, histidine (25 mM) was infused through a microdialysis probe; iron (II) failed to increase the 2,3-DHBA formation obtained. To examine the effect of histidine on ischemia-reperfusion of the myocardium, the heart was subjected to myocardial ischemia for 15 min by occlusion of the left anterior descending coronary artery (LAD). When the heart was reperfused, a marked elevation of the levels of 2,3-DHBA was observed in the heart dialysate. When corresponding experiments were performed with histidine (25 mM)-pretreated animals, histidine prevented the ischemia-reperfusion induced .OH generation trapped as 2,3-DHBA. These results indicate that histidine protects the myocardium against ischemia-reperfusion damage by .OH generation." @default.
- W2016906427 created "2016-06-24" @default.
- W2016906427 creator A5009113447 @default.
- W2016906427 creator A5023328943 @default.
- W2016906427 creator A5077870261 @default.
- W2016906427 date "1999-05-01" @default.
- W2016906427 modified "2023-09-27" @default.
- W2016906427 title "Protective effect of histidine on iron (II)-induced hydroxyl radical generation in rat hearts" @default.
- W2016906427 cites W1879184430 @default.
- W2016906427 cites W1978584900 @default.
- W2016906427 cites W1984202672 @default.
- W2016906427 cites W1985285096 @default.
- W2016906427 cites W1986932593 @default.
- W2016906427 cites W1995541277 @default.
- W2016906427 cites W1999220416 @default.
- W2016906427 cites W2013308696 @default.
- W2016906427 cites W2018032623 @default.
- W2016906427 cites W2021390693 @default.
- W2016906427 cites W2024560631 @default.
- W2016906427 cites W2026849188 @default.
- W2016906427 cites W2027237051 @default.
- W2016906427 cites W2051166021 @default.
- W2016906427 cites W2052126756 @default.
- W2016906427 cites W2053145973 @default.
- W2016906427 cites W2055033774 @default.
- W2016906427 cites W2055371996 @default.
- W2016906427 cites W2061908192 @default.
- W2016906427 cites W2069563551 @default.
- W2016906427 cites W2078376971 @default.
- W2016906427 cites W2097744068 @default.
- W2016906427 doi "https://doi.org/10.1016/s0928-4257(99)80153-3" @default.
- W2016906427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10399676" @default.
- W2016906427 hasPublicationYear "1999" @default.
- W2016906427 type Work @default.
- W2016906427 sameAs 2016906427 @default.
- W2016906427 citedByCount "8" @default.
- W2016906427 countsByYear W20169064272013 @default.
- W2016906427 countsByYear W20169064272016 @default.
- W2016906427 countsByYear W20169064272018 @default.
- W2016906427 countsByYear W20169064272022 @default.
- W2016906427 crossrefType "journal-article" @default.
- W2016906427 hasAuthorship W2016906427A5009113447 @default.
- W2016906427 hasAuthorship W2016906427A5023328943 @default.
- W2016906427 hasAuthorship W2016906427A5077870261 @default.
- W2016906427 hasConcept C126322002 @default.
- W2016906427 hasConcept C139066938 @default.
- W2016906427 hasConcept C178790620 @default.
- W2016906427 hasConcept C185592680 @default.
- W2016906427 hasConcept C2776778087 @default.
- W2016906427 hasConcept C2778460671 @default.
- W2016906427 hasConcept C2779134981 @default.
- W2016906427 hasConcept C28406088 @default.
- W2016906427 hasConcept C50156730 @default.
- W2016906427 hasConcept C515207424 @default.
- W2016906427 hasConcept C541997718 @default.
- W2016906427 hasConcept C55493867 @default.
- W2016906427 hasConcept C71924100 @default.
- W2016906427 hasConcept C98274493 @default.
- W2016906427 hasConceptScore W2016906427C126322002 @default.
- W2016906427 hasConceptScore W2016906427C139066938 @default.
- W2016906427 hasConceptScore W2016906427C178790620 @default.
- W2016906427 hasConceptScore W2016906427C185592680 @default.
- W2016906427 hasConceptScore W2016906427C2776778087 @default.
- W2016906427 hasConceptScore W2016906427C2778460671 @default.
- W2016906427 hasConceptScore W2016906427C2779134981 @default.
- W2016906427 hasConceptScore W2016906427C28406088 @default.
- W2016906427 hasConceptScore W2016906427C50156730 @default.
- W2016906427 hasConceptScore W2016906427C515207424 @default.
- W2016906427 hasConceptScore W2016906427C541997718 @default.
- W2016906427 hasConceptScore W2016906427C55493867 @default.
- W2016906427 hasConceptScore W2016906427C71924100 @default.
- W2016906427 hasConceptScore W2016906427C98274493 @default.
- W2016906427 hasIssue "3" @default.
- W2016906427 hasLocation W20169064271 @default.
- W2016906427 hasLocation W20169064272 @default.
- W2016906427 hasOpenAccess W2016906427 @default.
- W2016906427 hasPrimaryLocation W20169064271 @default.
- W2016906427 hasRelatedWork W1560859671 @default.
- W2016906427 hasRelatedWork W1978803387 @default.
- W2016906427 hasRelatedWork W1985229791 @default.
- W2016906427 hasRelatedWork W2016906427 @default.
- W2016906427 hasRelatedWork W2019349396 @default.
- W2016906427 hasRelatedWork W2048707344 @default.
- W2016906427 hasRelatedWork W2053029631 @default.
- W2016906427 hasRelatedWork W2086751397 @default.
- W2016906427 hasRelatedWork W3146632740 @default.
- W2016906427 hasRelatedWork W2009081094 @default.
- W2016906427 hasVolume "93" @default.
- W2016906427 isParatext "false" @default.
- W2016906427 isRetracted "false" @default.
- W2016906427 magId "2016906427" @default.
- W2016906427 workType "article" @default.