Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016909282> ?p ?o ?g. }
- W2016909282 endingPage "625" @default.
- W2016909282 startingPage "613" @default.
- W2016909282 abstract "In this study, we examined whether ischemia-induced amyloidogenesis could be modulated by environmental experience, and whether this modulation is associated with improved cognitive functioning. Rats were subjected to either global ischemia or sham surgery and then were randomly assigned to either enriched environment housing (EE) or socially paired housing (controls). After 14 days of differential environmental housing, the rats were tested in the water maze. Our results show decreased C-terminal fragments of the beta-amyloid precursor protein (betaAPP) and decreased amyloid beta (Abeta) load in the ischemic EE rats compared to the ischemic control animals. In addition, Abeta oligomerization was significantly decreased in the ischemic EE animals compared to the ischemic control rats. Further, significantly increased levels of neprilysin, but not insulin-degrading enzyme, amyloid-degrading enzymes, were seen in the ischemic EE rats compared to the ischemic control animals. Behavioral analyses showed that ischemic EE rats performed significantly better on the memory task compared to the ischemic control group. These results suggest that use of multi-sensory environmental enrichment following cerebral ischemia may reduce the accumulation of Abeta peptide in the more pathologic oligomeric form, and consequently may enhance functional recovery." @default.
- W2016909282 created "2016-06-24" @default.
- W2016909282 creator A5049199009 @default.
- W2016909282 creator A5067960333 @default.
- W2016909282 creator A5091047276 @default.
- W2016909282 date "2009-04-01" @default.
- W2016909282 modified "2023-10-16" @default.
- W2016909282 title "Environmental Experience Modulates Ischemia-Induced Amyloidogenesis and Enhances Functional Recovery" @default.
- W2016909282 cites W1762207349 @default.
- W2016909282 cites W1852458835 @default.
- W2016909282 cites W1904343043 @default.
- W2016909282 cites W1964038928 @default.
- W2016909282 cites W1964049915 @default.
- W2016909282 cites W1964332391 @default.
- W2016909282 cites W1981107891 @default.
- W2016909282 cites W1981488800 @default.
- W2016909282 cites W1983800998 @default.
- W2016909282 cites W1995186464 @default.
- W2016909282 cites W1995582522 @default.
- W2016909282 cites W1995839405 @default.
- W2016909282 cites W1996995902 @default.
- W2016909282 cites W1998940627 @default.
- W2016909282 cites W2000783952 @default.
- W2016909282 cites W2004739315 @default.
- W2016909282 cites W2005320724 @default.
- W2016909282 cites W2007668542 @default.
- W2016909282 cites W2008092392 @default.
- W2016909282 cites W2019255698 @default.
- W2016909282 cites W2020397140 @default.
- W2016909282 cites W2021807074 @default.
- W2016909282 cites W2025218528 @default.
- W2016909282 cites W2025492442 @default.
- W2016909282 cites W2027585389 @default.
- W2016909282 cites W2033817137 @default.
- W2016909282 cites W2038108333 @default.
- W2016909282 cites W2038112334 @default.
- W2016909282 cites W2040852295 @default.
- W2016909282 cites W2042481675 @default.
- W2016909282 cites W2044569346 @default.
- W2016909282 cites W2045489208 @default.
- W2016909282 cites W2046759860 @default.
- W2016909282 cites W2047776513 @default.
- W2016909282 cites W2048400917 @default.
- W2016909282 cites W2050864924 @default.
- W2016909282 cites W2051997581 @default.
- W2016909282 cites W2054898602 @default.
- W2016909282 cites W2059212904 @default.
- W2016909282 cites W2060043433 @default.
- W2016909282 cites W2062124644 @default.
- W2016909282 cites W2063982984 @default.
- W2016909282 cites W2065904280 @default.
- W2016909282 cites W2067281910 @default.
- W2016909282 cites W2067813401 @default.
- W2016909282 cites W2070061539 @default.
- W2016909282 cites W2076517751 @default.
- W2016909282 cites W2077935628 @default.
- W2016909282 cites W2080482523 @default.
- W2016909282 cites W2081113831 @default.
- W2016909282 cites W2085450230 @default.
- W2016909282 cites W2086271635 @default.
- W2016909282 cites W2087651523 @default.
- W2016909282 cites W2088608159 @default.
- W2016909282 cites W2090737341 @default.
- W2016909282 cites W2094450440 @default.
- W2016909282 cites W2094588071 @default.
- W2016909282 cites W2096192426 @default.
- W2016909282 cites W2099370040 @default.
- W2016909282 cites W2116734848 @default.
- W2016909282 cites W2129337589 @default.
- W2016909282 cites W2134613265 @default.
- W2016909282 cites W2152093646 @default.
- W2016909282 cites W2155133303 @default.
- W2016909282 cites W2164735970 @default.
- W2016909282 cites W51964316 @default.
- W2016909282 doi "https://doi.org/10.1089/neu.2008.0707" @default.
- W2016909282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2848830" @default.
- W2016909282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19271963" @default.
- W2016909282 hasPublicationYear "2009" @default.
- W2016909282 type Work @default.
- W2016909282 sameAs 2016909282 @default.
- W2016909282 citedByCount "23" @default.
- W2016909282 countsByYear W20169092822012 @default.
- W2016909282 countsByYear W20169092822013 @default.
- W2016909282 countsByYear W20169092822014 @default.
- W2016909282 countsByYear W20169092822015 @default.
- W2016909282 countsByYear W20169092822016 @default.
- W2016909282 countsByYear W20169092822017 @default.
- W2016909282 countsByYear W20169092822019 @default.
- W2016909282 countsByYear W20169092822021 @default.
- W2016909282 crossrefType "journal-article" @default.
- W2016909282 hasAuthorship W2016909282A5049199009 @default.
- W2016909282 hasAuthorship W2016909282A5067960333 @default.
- W2016909282 hasAuthorship W2016909282A5091047276 @default.
- W2016909282 hasBestOaLocation W20169092822 @default.
- W2016909282 hasConcept C104826730 @default.
- W2016909282 hasConcept C126322002 @default.
- W2016909282 hasConcept C134018914 @default.
- W2016909282 hasConcept C181199279 @default.