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- W2016912250 abstract "A considerable amount of research has focused on elucidating the mechanisms by which cytokines synthesized by cells of the innate immune system participate in the life-threatening multiple-organ failure of endotoxic shock. We show here that αβ T cells, which are archetypes of the adaptive cellular immune response, suppress the proinflammatory cascade triggered during the early stages of lipopolysaccharide (LPS)–induced endotoxemia. The absence of αβ T cells led to the fulminant death of LPS-challenged mice, coinciding with a massive release of the proinflammatory cytokines tumor necrosis factor (TNF)–α and interferon (IFN)–γ and a marked reduction in the synthesis of the immunosuppressive cytokine transforming growth factor (TGF)–β. Cytotoxic T lymphocyte antigen (CTLA)–positive αβ T cells emerging shortly after LPS challenge appear to control TGF-β synthesis. The neutralization of either TGF-β or CTLA4 resulted in similar increases in IFN-γ and TNF-α serum concentrations in LPS-challenged mice. These observations suggest that suppressor αβ T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia" @default.
- W2016912250 created "2016-06-24" @default.
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- W2016912250 date "2005-09-15" @default.
- W2016912250 modified "2023-10-03" @default.
- W2016912250 title "Suppressor αβ T Lymphocytes Control Innate Resistance to Endotoxic Shock" @default.
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- W2016912250 doi "https://doi.org/10.1086/432727" @default.
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