FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016930899> ?p ?o ?g. }

• W2016930899 endingPage "866" @default.
• W2016930899 startingPage "861" @default.
• W2016930899 abstract "We investigated the protective effects of two non-steroid anti-inflammatory drugs, indomethacin (COX-1 and COX-2 inhibitors) and nimesulide (specific COX-2 inhibitor) on the hepatic injury induced by lipopolysaccharide in d-galactosamine sensitized (Gal/LPS) mice. ICR male mice were injected with a single dose of Gal/LPS with or without pre-treatment of 3 mg/kg indomethacin or 30 mg/kg nimesulide (single i.p. injection). Sixteen hours later, blood and liver tissues of mice were collected for histological, molecular, and biochemical analyses. Our results showed marked reduction of hepatic necrosis, serum ALT, and tissue TBARS levels in both indomethacin- and nimesulide-pre-treated mice when compared with Gal/LPS-treated mice. Western blot and RT-PCR analysis showed decreased levels of iNOS mRNA, iNOS protein, and nitrotyrosine formation in both COX inhibitor pre-treated groups when compared with Gal/LPS-treated group. There was an inverse relationship between COX-1 and COX-2 expressions, as well as between COX-2 and C/EBP-α expressions in COX inhibitors groups, Gal/LPS and control groups. COX inhibitors reduced the expression of TNF-α mRNA and the activity of NF-κB which were elevated by Gal/LPS treatment. We conclude that COX inhibitors protected the liver from Gal/LPS-induced hepatotoxicity. COX inhibitors could be considered as potential agents in the prevention of acute liver failure and sepsis." @default.
• W2016930899 created "2016-06-24" @default.
• W2016930899 creator A5017505168 @default.
• W2016930899 creator A5025465143 @default.
• W2016930899 creator A5077093072 @default.
• W2016930899 creator A5083467029 @default.
• W2016930899 creator A5090217037 @default.
• W2016930899 date "2012-03-01" @default.
• W2016930899 modified "2023-10-01" @default.
• W2016930899 title "Cyclooxygenase inhibitors protect d-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model" @default.
• W2016930899 cites W1971427229 @default.
• W2016930899 cites W1976355152 @default.
• W2016930899 cites W1980031261 @default.
• W2016930899 cites W1980125545 @default.
• W2016930899 cites W1983019597 @default.
• W2016930899 cites W2012508659 @default.
• W2016930899 cites W2015544462 @default.
• W2016930899 cites W2021737033 @default.
• W2016930899 cites W2022931055 @default.
• W2016930899 cites W2024289681 @default.
• W2016930899 cites W2032654952 @default.
• W2016930899 cites W2036015712 @default.
• W2016930899 cites W2044691326 @default.
• W2016930899 cites W2048278498 @default.
• W2016930899 cites W2050295100 @default.
• W2016930899 cites W2050389359 @default.
• W2016930899 cites W2057328758 @default.
• W2016930899 cites W2062835892 @default.
• W2016930899 cites W2067278135 @default.
• W2016930899 cites W2073976519 @default.
• W2016930899 cites W2087203965 @default.
• W2016930899 cites W2088313062 @default.
• W2016930899 cites W2090439142 @default.
• W2016930899 cites W2090964375 @default.
• W2016930899 cites W2097086662 @default.
• W2016930899 cites W2104564467 @default.
• W2016930899 cites W2108441239 @default.
• W2016930899 cites W2129011493 @default.
• W2016930899 cites W2130760807 @default.
• W2016930899 cites W2144847280 @default.
• W2016930899 cites W2152071237 @default.
• W2016930899 cites W2154746436 @default.
• W2016930899 cites W2162663926 @default.
• W2016930899 cites W2163144555 @default.
• W2016930899 doi "https://doi.org/10.1016/j.fct.2011.11.009" @default.
• W2016930899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22107987" @default.
• W2016930899 hasPublicationYear "2012" @default.
• W2016930899 type Work @default.
• W2016930899 sameAs 2016930899 @default.
• W2016930899 citedByCount "19" @default.
• W2016930899 countsByYear W20169308992012 @default.
• W2016930899 countsByYear W20169308992013 @default.
• W2016930899 countsByYear W20169308992014 @default.
• W2016930899 countsByYear W20169308992015 @default.
• W2016930899 countsByYear W20169308992016 @default.
• W2016930899 countsByYear W20169308992017 @default.
• W2016930899 countsByYear W20169308992019 @default.
• W2016930899 countsByYear W20169308992020 @default.
• W2016930899 countsByYear W20169308992022 @default.
• W2016930899 crossrefType "journal-article" @default.
• W2016930899 hasAuthorship W2016930899A5017505168 @default.
• W2016930899 hasAuthorship W2016930899A5025465143 @default.
• W2016930899 hasAuthorship W2016930899A5077093072 @default.
• W2016930899 hasAuthorship W2016930899A5083467029 @default.
• W2016930899 hasAuthorship W2016930899A5090217037 @default.
• W2016930899 hasConcept C104317684 @default.
• W2016930899 hasConcept C126322002 @default.
• W2016930899 hasConcept C181199279 @default.
• W2016930899 hasConcept C185592680 @default.
• W2016930899 hasConcept C2776415932 @default.
• W2016930899 hasConcept C2776637226 @default.
• W2016930899 hasConcept C2777570176 @default.
• W2016930899 hasConcept C2777622882 @default.
• W2016930899 hasConcept C2778125326 @default.
• W2016930899 hasConcept C2778754761 @default.
• W2016930899 hasConcept C2779385521 @default.
• W2016930899 hasConcept C2779689624 @default.
• W2016930899 hasConcept C2781467277 @default.
• W2016930899 hasConcept C55493867 @default.
• W2016930899 hasConcept C71924100 @default.
• W2016930899 hasConcept C98274493 @default.
• W2016930899 hasConceptScore W2016930899C104317684 @default.
• W2016930899 hasConceptScore W2016930899C126322002 @default.
• W2016930899 hasConceptScore W2016930899C181199279 @default.
• W2016930899 hasConceptScore W2016930899C185592680 @default.
• W2016930899 hasConceptScore W2016930899C2776415932 @default.
• W2016930899 hasConceptScore W2016930899C2776637226 @default.
• W2016930899 hasConceptScore W2016930899C2777570176 @default.
• W2016930899 hasConceptScore W2016930899C2777622882 @default.
• W2016930899 hasConceptScore W2016930899C2778125326 @default.
• W2016930899 hasConceptScore W2016930899C2778754761 @default.
• W2016930899 hasConceptScore W2016930899C2779385521 @default.
• W2016930899 hasConceptScore W2016930899C2779689624 @default.
• W2016930899 hasConceptScore W2016930899C2781467277 @default.
• W2016930899 hasConceptScore W2016930899C55493867 @default.
• W2016930899 hasConceptScore W2016930899C71924100 @default.
• W2016930899 hasConceptScore W2016930899C98274493 @default.
• W2016930899 hasIssue "3-4" @default.

• next