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- W2016952830 endingPage "22" @default.
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- W2016952830 abstract "This Review describes the unique biology of the eosinophil. The authors explain how eosinophils interact with other leukocyte populations to promote protective immunity following infection. They also discuss the pathological roles of eosinophils in allergic-type diseases, such as asthma and the hypereosinophilic syndromes. Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector cells. Recent studies have profoundly altered this simplistic view of eosinophils and their function. New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved our understanding of the immunomodulatory functions of these cells and their roles in promoting homeostasis. Likewise, recent developments have generated a more sophisticated view of how eosinophils contribute to the pathogenesis of different diseases, including asthma and primary hypereosinophilic syndromes, and have also provided us with a more complete appreciation of the activities of these cells during parasitic infection." @default.
- W2016952830 created "2016-06-24" @default.
- W2016952830 creator A5020510223 @default.
- W2016952830 creator A5043300180 @default.
- W2016952830 creator A5068150354 @default.
- W2016952830 date "2012-11-16" @default.
- W2016952830 modified "2023-10-16" @default.
- W2016952830 title "Eosinophils: changing perspectives in health and disease" @default.
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