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• W2016962699 abstract "Prointerleukin-16 (Pro-IL-16) is an abundant, PDZ domain-containing protein expressed in the nucleus and cytoplasm of resting human T lymphocytes. We have previously shown that ectopic expression of Pro-IL-16 in Pro-IL-16-negative human Jurkat cells represses transcription of the F-box protein, Skp2, resulting in accumulation of the cyclin-dependent kinase inhibitor, p27Kip1, and G0/G1 cell cycle arrest. The current studies demonstrate the kinetics of Pro-IL-16 and p27Kip1 expression in activated normal human T lymphocytes. We correlate nuclear Pro-IL-16 loss with decreased p27Kip1 expression, increased cell cycle progression, and proliferation. Conversely, we show that constitutive expression of Pro-IL-16 by retroviral infection of activated human T lymphocytes induces G0/G1 cell cycle arrest, inhibits proliferation, and is associated with increased levels of p27Kip1. These findings implicate nuclear Pro-IL-16 as a cell cycle regulatory protein for human T lymphocytes." @default.
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• W2016962699 date "2005-09-01" @default.
• W2016962699 modified "2023-10-03" @default.
• W2016962699 title "Regulation of nuclear Prointerleukin-16 and p27Kip1 in primary human T lymphocytes" @default.
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• W2016962699 doi "https://doi.org/10.1016/j.cellimm.2005.09.003" @default.
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