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- W2016965372 abstract "The relative rates of reduction of a series of simple phenyl azides by dithiothreitol (DTT) were studied and the results modelled using the Hammett equation. The rate of reduction was found to be dependent on electronic effects and the steric environment of the azido group, with electron-deficient aryl azides being reduced at a faster rate. These findings were extended to study the reduction rates of model azido-2,4-diaminopyrimidine drugs by DTT, and showed similar dependence on electronic and steric considerations. The findings have implications for the design of aromatic azido pro-drugs and “soft drugs”, from the point of view of bioreductive susceptibility." @default.
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- W2016965372 title "The reduction of aryl azides by dithiothreitol: a model for bioreduction of aromatic azido-substituted drugs" @default.
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- W2016965372 doi "https://doi.org/10.1016/0378-5173(89)90225-1" @default.
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