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• W2016974788 abstract "In continuation of our evolutionary studies of immunoglobulin (Ig) expression, we present here the cloning of IgE from a monotreme, the short-beaked echidna (Tachyglossus aculeatus). Including echidna IgE, 15 ε chain sequences have been isolated and each of the three mammalian lineages (placentals, marsupials and monotremes) is now represented by at least two sequences. Phylogenetic analyses based on all available ε chains and a selection of other mammalian Ig isotypes (IgM, IgA and IgG) were generated using three different algorithms. The resulting trees strongly support the Theria hypothesis, which states that the monotreme lineage was the first of the three extant mammalian lineages to appear in evolution. Furthermore, to increase our understanding of IgE we have done a detailed comparative analysis, with focus on primary structure, potential N-glycosylation, charge distribution and conservation of residues in the putative receptor-binding site. The overall structure of IgE, i.e. four constant domains and the positions of putative disulfide-bridge formations, are conserved, as is an N-glycosylation site in the third constant domain. An increased homology was observed in the putative receptor-binding site, which suggests an important function for the IgE/FcεRI interaction. IgE has been found exclusively in mammals, but it is present in all extant mammalian lineages. This, together with the overall conservation of structure, indicates that IgE appeared as a separate isotype early in mammalian evolution and that structural maintenance may have a selective advantage." @default.
• W2016974788 created "2016-06-24" @default.
• W2016974788 creator A5009009085 @default.
• W2016974788 creator A5013188694 @default.
• W2016974788 creator A5023032556 @default.
• W2016974788 date "2004-01-01" @default.
• W2016974788 modified "2023-10-16" @default.
• W2016974788 title "Cloning of IgE from the echidna (Tachyglossus aculeatus) and a comparative analysis of ε chains from all three extant mammalian lineages" @default.
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• W2016974788 doi "https://doi.org/10.1016/s0145-305x(03)00084-3" @default.
• W2016974788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12962983" @default.
• W2016974788 hasPublicationYear "2004" @default.
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