FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016980863> ?p ?o ?g. }

• W2016980863 abstract "Extracellular adenosine 5'-triphosphate (ATP) acts as a proinflammatory mediator. Adenosine, the final product of ATP breakdown, is an anti-inflammatory compound, acting mainly on adenosine A(2A) receptors. Considering that the kidney is an organ strongly affected during systemic inflammatory responses and that ectonucleotidases are responsible for the control of extracellular nucleotide and nucleoside levels, we examined the endotoxin-induced effects on ectonucleotidases in kidney membranes of mice, and whether CGS-21680 hydrochloride (3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid), a selective adenosine A(2A) receptor agonist, antagonizes the lipopolysaccharide (LPS)-induced effects on nucleotide catabolism in kidney. Animals were injected intraperitoneally with 12 mg/kg LPS and/or 0.5mg/kg CGS-21680 or saline. Nucleotidase activities were determined in kidney membrane preparations and ATP metabolism was measured by high performance liquid chromatography (HPLC) assay. Analysis of ectonucleotidase expression was carried out by semi-quantitative semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Exposure to endotoxemia promoted an increase in ATP and p-Nitrophenyl thymidine 5'-monophosphate (p-Nph-5'-TMP) hydrolysis, and a decrease in adenosine 5'-monophosphate (AMP) hydrolysis. CGS-21680 treatment failed to reverse these changes. HPLC analysis indicated a decrease in extracellular ATP and adenosine levels in groups treated with LPS and LPS plus CGS-21680. The expression pattern of ectonucleotidases revealed an increase in Entpd3, Enpp2, and Enpp3 mRNA levels after LPS injection. These findings indicate that nucleotide and nucleoside availability in mouse kidney is altered at different stages of endotoxemia, in order to protect the integrity of this organ when exposed to systemic inflammation." @default.
• W2016980863 created "2016-06-24" @default.
• W2016980863 creator A5008213735 @default.
• W2016980863 creator A5016013778 @default.
• W2016980863 creator A5068680303 @default.
• W2016980863 creator A5088109532 @default.
• W2016980863 creator A5089940228 @default.
• W2016980863 creator A5090314436 @default.
• W2016980863 date "2012-01-01" @default.
• W2016980863 modified "2023-09-26" @default.
• W2016980863 title "Endotoxin-induced effects on nucleotide catabolism in mouse kidney" @default.
• W2016980863 cites W1489794536 @default.
• W2016980863 cites W1525984439 @default.
• W2016980863 cites W1557275969 @default.
• W2016980863 cites W1598030966 @default.
• W2016980863 cites W161060649 @default.
• W2016980863 cites W1655860314 @default.
• W2016980863 cites W180620693 @default.
• W2016980863 cites W1965600560 @default.
• W2016980863 cites W1967402902 @default.
• W2016980863 cites W1967412131 @default.
• W2016980863 cites W1969761928 @default.
• W2016980863 cites W1972005675 @default.
• W2016980863 cites W1977251749 @default.
• W2016980863 cites W1980336273 @default.
• W2016980863 cites W1980352092 @default.
• W2016980863 cites W1981424925 @default.
• W2016980863 cites W1989000067 @default.
• W2016980863 cites W1992008256 @default.
• W2016980863 cites W1994060241 @default.
• W2016980863 cites W1999746425 @default.
• W2016980863 cites W2009401980 @default.
• W2016980863 cites W2016582727 @default.
• W2016980863 cites W2018130919 @default.
• W2016980863 cites W2031084334 @default.
• W2016980863 cites W2031462278 @default.
• W2016980863 cites W2031529680 @default.
• W2016980863 cites W2031924525 @default.
• W2016980863 cites W2034442219 @default.
• W2016980863 cites W2035275513 @default.
• W2016980863 cites W2038629532 @default.
• W2016980863 cites W2042906495 @default.
• W2016980863 cites W2045606714 @default.
• W2016980863 cites W2053570360 @default.
• W2016980863 cites W2053643150 @default.
• W2016980863 cites W2069271283 @default.
• W2016980863 cites W2077971241 @default.
• W2016980863 cites W2078791944 @default.
• W2016980863 cites W2082539152 @default.
• W2016980863 cites W2084383502 @default.
• W2016980863 cites W2084940833 @default.
• W2016980863 cites W2086834997 @default.
• W2016980863 cites W2096081051 @default.
• W2016980863 cites W2102149343 @default.
• W2016980863 cites W2108723776 @default.
• W2016980863 cites W2111178472 @default.
• W2016980863 cites W2117100825 @default.
• W2016980863 cites W2123247443 @default.
• W2016980863 cites W2125075553 @default.
• W2016980863 cites W2137500094 @default.
• W2016980863 cites W2166723463 @default.
• W2016980863 cites W2321822925 @default.
• W2016980863 cites W30353035 @default.
• W2016980863 cites W4293247451 @default.
• W2016980863 doi "https://doi.org/10.1016/j.ejphar.2011.11.002" @default.
• W2016980863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22108548" @default.
• W2016980863 hasPublicationYear "2012" @default.
• W2016980863 type Work @default.
• W2016980863 sameAs 2016980863 @default.
• W2016980863 citedByCount "6" @default.
• W2016980863 countsByYear W20169808632013 @default.
• W2016980863 countsByYear W20169808632014 @default.
• W2016980863 countsByYear W20169808632017 @default.
• W2016980863 countsByYear W20169808632018 @default.
• W2016980863 crossrefType "journal-article" @default.
• W2016980863 hasAuthorship W2016980863A5008213735 @default.
• W2016980863 hasAuthorship W2016980863A5016013778 @default.
• W2016980863 hasAuthorship W2016980863A5068680303 @default.
• W2016980863 hasAuthorship W2016980863A5088109532 @default.
• W2016980863 hasAuthorship W2016980863A5089940228 @default.
• W2016980863 hasAuthorship W2016980863A5090314436 @default.
• W2016980863 hasBestOaLocation W20169808631 @default.
• W2016980863 hasConcept C104317684 @default.
• W2016980863 hasConcept C170493617 @default.
• W2016980863 hasConcept C172590197 @default.
• W2016980863 hasConcept C185592680 @default.
• W2016980863 hasConcept C2776543447 @default.
• W2016980863 hasConcept C2776991684 @default.
• W2016980863 hasConcept C2777610669 @default.
• W2016980863 hasConcept C2778938600 @default.
• W2016980863 hasConcept C2779876172 @default.
• W2016980863 hasConcept C2780231331 @default.
• W2016980863 hasConcept C28406088 @default.
• W2016980863 hasConcept C2994266630 @default.
• W2016980863 hasConcept C512185932 @default.
• W2016980863 hasConcept C55493867 @default.
• W2016980863 hasConcept C67907053 @default.
• W2016980863 hasConceptScore W2016980863C104317684 @default.
• W2016980863 hasConceptScore W2016980863C170493617 @default.
• W2016980863 hasConceptScore W2016980863C172590197 @default.

• next