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• W2016980922 abstract "This study evaluated bone and cementum regeneration following periodontal reconstructive surgery using recombinant human bone morphogenetic protein-2 (rhBMP2) in six beagle dogs. Surgically created mandibular supraalveolar premolar tooth defects in contralateral jaw quadrants were randomly assigned to receive rhBMP-2 or control vehicle. Clinical defect height was prepared to 5 mm. rhBMP-2 was applied with synthetic bioerodable particles and autologous blood using 20 μg rhBMP-2 per 100 μl implant volume. Flaps were advanced to submerge the teeth and sutured. The dogs were sacrificed 8 weeks postsurgery. Histometric recordings included defect height, height and area of alveolar bone regeneration, height of cementum regeneration, root resorption, and ankylosis. Group means, standard deviations, and P values are shown (Student t test; n = 6). Histometric defect height for rhBMP-2 and control defects was 3.7±0.3 and 3.9±0.4 mm, respectively (P = 0.446). Height of alveolar bone regeneration amounted to 3.5±0.6 and 0.8±0.6 mm for rhBMP-2 and control defects, respectively (P = 0.000). Corresponding values for bone area were 8.4±4.5 and 0.4±0.5 mm2, respectively (P = 0.006). Cementum regeneration was observed in all experimental defects (17/17) and in 15 out of 17 controls, averaging 1.6±0.6 and 0.4±0.3 mm for rhBMP-2 and control defects, respectively (P = 0.005). Small amounts of root resorption were seen in rhBMP2 defects, whereas controls exhibited substantial resorption (0.2±0.1 and 1.1±0.3 mm, respectively; P = 0.001). When present, ankylosis was limited and localized in both rhBMP-2 and control defects, suggesting it was unrelated to the experimental variable. Our data suggest that wound conditioning with rhBMP-2 has a significant potential for stimulating periodontal regeneration. J Periodontol 1995; 66:131–138." @default.
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• W2016980922 date "1995-02-01" @default.
• W2016980922 modified "2023-10-02" @default.
• W2016980922 title "Periodontal Repair in Dogs: Recombinant Human Bone Morphogenetic Protein‐2 Significantly Enhances Periodontal Regeneration" @default.
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• W2016980922 doi "https://doi.org/10.1902/jop.1995.66.2.131" @default.
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