FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016980959> ?p ?o ?g. }

• W2016980959 endingPage "S274" @default.
• W2016980959 startingPage "S274" @default.
• W2016980959 abstract "As a member of the TGF-B superfamily of growth factors, myostatin is a potent negative regulator of muscle mass that inhibits proliferation and differentiation of both myoblasts during development and satellite cells in adult myofibers undergoing regeneration/growth processes. Myostatin (aka GDF-8) is synthesized in pro-form (375 aa). Two important cleavage steps result in loss of the 23 aa signal sequence from the N-terminus and cleavage of the 109 aa active C-terminal peptide (12 kD) at residue 266, leaving behind its 28 kD latent-associated peptide (LAP). The active peptide apparently does not remain in free form long as we and others have not identified it in human muscle lysates, while LAP is found in relatively high concentration. PURPOSE: To determine 1) basal and resistance training (RT)-mediated changes in myostatin LAP protein in young (Y) and older (O) males (M) and females (F); and 2) whether protein changes with RT are similar to our previously characterized transcriptlevel responses. METHODS: Twenty five Y (20–35 yr, 11 YF, 14 YM) and 25 O (60–75 yr, 13 OF, 12 OM) consented to vastus lateralis biopsy prior to loading, 24 h after the first full loading bout (3 sets x 8–12 repetitions with 80% 1RM squat, leg press, knee extension), and after 16 wk of 3 d/wk RT. Myostatin LAP levels were determined by immunoblotting with a thoroughly tested antibody and analyzed by age x gender x time repeated measures ANOVA. Zero-order correlations were tested between resting levels of myostatin LAP protein and levels of thigh lean mass (TLM) or cross sectional area (CSA) of 3 fiber types (I, IIa, and IIx). RESULTS: M express 28% (P<0.05) more myostatin than F and Y express 31% (P<0.05) more than O adults. Tukey post hoc analyses revealed that these main age and gender effects were driven primarily by the greater myostatin protein expression in YM vs. OF (66%, P<0.005). RT did not alter myostatin expression. Basal myostatin LAP levels were positively correlated with baseline TLM (r = 0.35, P<0.05) and type II CSA (r = 0.52, P<0.0001). CONCLUSIONS: Our results indicate that healthy sedentary individuals with a larger muscle mass and greater type II fiber CSA express more myostatin protein at rest, which is in agreement with our previous transcript-level findings. However, unlike mRNA concentration, myostatin protein levels do not decline in response to a single loading bout, nor after 16 wk of RT. Funded by R01 AG17896 and GCRC M01 RR00032." @default.
• W2016980959 created "2016-06-24" @default.
• W2016980959 creator A5031857488 @default.
• W2016980959 creator A5034603408 @default.
• W2016980959 creator A5058873829 @default.
• W2016980959 creator A5068081365 @default.
• W2016980959 creator A5078628997 @default.
• W2016980959 date "2006-05-01" @default.
• W2016980959 modified "2023-10-12" @default.
• W2016980959 title "Age and Gender Differences in Muscle Myostatin across 16 Wk of Resistance Training" @default.
• W2016980959 doi "https://doi.org/10.1249/00005768-200605001-02064" @default.
• W2016980959 hasPublicationYear "2006" @default.
• W2016980959 type Work @default.
• W2016980959 sameAs 2016980959 @default.
• W2016980959 citedByCount "0" @default.
• W2016980959 crossrefType "journal-article" @default.
• W2016980959 hasAuthorship W2016980959A5031857488 @default.
• W2016980959 hasAuthorship W2016980959A5034603408 @default.
• W2016980959 hasAuthorship W2016980959A5058873829 @default.
• W2016980959 hasAuthorship W2016980959A5068081365 @default.
• W2016980959 hasAuthorship W2016980959A5078628997 @default.
• W2016980959 hasBestOaLocation W20169809591 @default.
• W2016980959 hasConcept C104317684 @default.
• W2016980959 hasConcept C10858879 @default.
• W2016980959 hasConcept C126322002 @default.
• W2016980959 hasConcept C134018914 @default.
• W2016980959 hasConcept C16685009 @default.
• W2016980959 hasConcept C167414201 @default.
• W2016980959 hasConcept C167625842 @default.
• W2016980959 hasConcept C207200792 @default.
• W2016980959 hasConcept C2777488582 @default.
• W2016980959 hasConcept C2777861855 @default.
• W2016980959 hasConcept C2778820510 @default.
• W2016980959 hasConcept C2779281246 @default.
• W2016980959 hasConcept C3019424981 @default.
• W2016980959 hasConcept C42407357 @default.
• W2016980959 hasConcept C55493867 @default.
• W2016980959 hasConcept C71924100 @default.
• W2016980959 hasConcept C86803240 @default.
• W2016980959 hasConceptScore W2016980959C104317684 @default.
• W2016980959 hasConceptScore W2016980959C10858879 @default.
• W2016980959 hasConceptScore W2016980959C126322002 @default.
• W2016980959 hasConceptScore W2016980959C134018914 @default.
• W2016980959 hasConceptScore W2016980959C16685009 @default.
• W2016980959 hasConceptScore W2016980959C167414201 @default.
• W2016980959 hasConceptScore W2016980959C167625842 @default.
• W2016980959 hasConceptScore W2016980959C207200792 @default.
• W2016980959 hasConceptScore W2016980959C2777488582 @default.
• W2016980959 hasConceptScore W2016980959C2777861855 @default.
• W2016980959 hasConceptScore W2016980959C2778820510 @default.
• W2016980959 hasConceptScore W2016980959C2779281246 @default.
• W2016980959 hasConceptScore W2016980959C3019424981 @default.
• W2016980959 hasConceptScore W2016980959C42407357 @default.
• W2016980959 hasConceptScore W2016980959C55493867 @default.
• W2016980959 hasConceptScore W2016980959C71924100 @default.
• W2016980959 hasConceptScore W2016980959C86803240 @default.
• W2016980959 hasIssue "Supplement" @default.
• W2016980959 hasLocation W20169809591 @default.
• W2016980959 hasLocation W20169809592 @default.
• W2016980959 hasOpenAccess W2016980959 @default.
• W2016980959 hasPrimaryLocation W20169809591 @default.
• W2016980959 hasRelatedWork W1981654342 @default.
• W2016980959 hasRelatedWork W1995833662 @default.
• W2016980959 hasRelatedWork W2050592095 @default.
• W2016980959 hasRelatedWork W2062221236 @default.
• W2016980959 hasRelatedWork W2082649210 @default.
• W2016980959 hasRelatedWork W2096008312 @default.
• W2016980959 hasRelatedWork W2123852334 @default.
• W2016980959 hasRelatedWork W2133828201 @default.
• W2016980959 hasRelatedWork W3106816079 @default.
• W2016980959 hasRelatedWork W3181454275 @default.
• W2016980959 hasVolume "38" @default.
• W2016980959 isParatext "false" @default.
• W2016980959 isRetracted "false" @default.
• W2016980959 magId "2016980959" @default.
• W2016980959 workType "article" @default.