Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016984261> ?p ?o ?g. }
- W2016984261 endingPage "508" @default.
- W2016984261 startingPage "501" @default.
- W2016984261 abstract "ADAMTS1 is a secreted protein that belongs to the recently described ADAMTS (a disintegrin and metalloprotease with thrombospondin repeats) family of proteases. Evaluation of ADAMTS1 catalytic activity on a panel of extracellular matrix proteins showed a restrictive substrate specificity which includes some proteoglycans. Our results demonstrated that human ADAMTS1 cleaves aggrecan at a previously shown site by its mouse homolog, but we have also identified additional cleavage sites that ultimately confirm the classification of this protease as an `aggrecanase'. Specificity of ADAMTS1 activity was further verified when a point mutation in the zinc-binding domain abolished its catalytic effects, and latency conferred by the prodomain was also demonstrated using a furin cleavage site mutant. Suppression of ADAMTS1 activity was accomplished with a specific monoclonal antibody and some metalloprotease inhibitors, including tissue inhibitor of metalloproteinases 2 and 3. Finally, we developed an activity assay using an artificial peptide substrate based on the interglobular domain cleavage site (E373–A) of rat aggrecan." @default.
- W2016984261 created "2016-06-24" @default.
- W2016984261 creator A5011640708 @default.
- W2016984261 creator A5013336086 @default.
- W2016984261 creator A5016235541 @default.
- W2016984261 creator A5055704539 @default.
- W2016984261 creator A5064268987 @default.
- W2016984261 creator A5066264000 @default.
- W2016984261 creator A5074621504 @default.
- W2016984261 creator A5091178052 @default.
- W2016984261 date "2002-04-01" @default.
- W2016984261 modified "2023-10-13" @default.
- W2016984261 title "ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors" @default.
- W2016984261 cites W1488836512 @default.
- W2016984261 cites W1494656326 @default.
- W2016984261 cites W1564633285 @default.
- W2016984261 cites W1895543855 @default.
- W2016984261 cites W1976831807 @default.
- W2016984261 cites W1984648902 @default.
- W2016984261 cites W1985469117 @default.
- W2016984261 cites W1995033273 @default.
- W2016984261 cites W2007799501 @default.
- W2016984261 cites W2009581109 @default.
- W2016984261 cites W2011576160 @default.
- W2016984261 cites W2028313997 @default.
- W2016984261 cites W2032541805 @default.
- W2016984261 cites W2035109568 @default.
- W2016984261 cites W2037732078 @default.
- W2016984261 cites W2037846454 @default.
- W2016984261 cites W2042589651 @default.
- W2016984261 cites W2045217734 @default.
- W2016984261 cites W2052827927 @default.
- W2016984261 cites W2065053969 @default.
- W2016984261 cites W2071583399 @default.
- W2016984261 cites W2079896426 @default.
- W2016984261 cites W2091174413 @default.
- W2016984261 cites W2093394571 @default.
- W2016984261 cites W2096352098 @default.
- W2016984261 cites W2110088633 @default.
- W2016984261 cites W2114769400 @default.
- W2016984261 cites W2116013040 @default.
- W2016984261 cites W2116169917 @default.
- W2016984261 cites W2121535505 @default.
- W2016984261 cites W2123811141 @default.
- W2016984261 cites W2142335737 @default.
- W2016984261 cites W2167869180 @default.
- W2016984261 cites W2236998588 @default.
- W2016984261 cites W332299311 @default.
- W2016984261 cites W4230631335 @default.
- W2016984261 cites W4254461284 @default.
- W2016984261 doi "https://doi.org/10.1016/s0006-291x(02)00254-1" @default.
- W2016984261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12054629" @default.
- W2016984261 hasPublicationYear "2002" @default.
- W2016984261 type Work @default.
- W2016984261 sameAs 2016984261 @default.
- W2016984261 citedByCount "213" @default.
- W2016984261 countsByYear W20169842612012 @default.
- W2016984261 countsByYear W20169842612013 @default.
- W2016984261 countsByYear W20169842612014 @default.
- W2016984261 countsByYear W20169842612015 @default.
- W2016984261 countsByYear W20169842612016 @default.
- W2016984261 countsByYear W20169842612017 @default.
- W2016984261 countsByYear W20169842612018 @default.
- W2016984261 countsByYear W20169842612019 @default.
- W2016984261 countsByYear W20169842612020 @default.
- W2016984261 countsByYear W20169842612021 @default.
- W2016984261 countsByYear W20169842612022 @default.
- W2016984261 countsByYear W20169842612023 @default.
- W2016984261 crossrefType "journal-article" @default.
- W2016984261 hasAuthorship W2016984261A5011640708 @default.
- W2016984261 hasAuthorship W2016984261A5013336086 @default.
- W2016984261 hasAuthorship W2016984261A5016235541 @default.
- W2016984261 hasAuthorship W2016984261A5055704539 @default.
- W2016984261 hasAuthorship W2016984261A5064268987 @default.
- W2016984261 hasAuthorship W2016984261A5066264000 @default.
- W2016984261 hasAuthorship W2016984261A5074621504 @default.
- W2016984261 hasAuthorship W2016984261A5091178052 @default.
- W2016984261 hasConcept C104317684 @default.
- W2016984261 hasConcept C109523444 @default.
- W2016984261 hasConcept C142724271 @default.
- W2016984261 hasConcept C143065580 @default.
- W2016984261 hasConcept C151730666 @default.
- W2016984261 hasConcept C153911025 @default.
- W2016984261 hasConcept C167814343 @default.
- W2016984261 hasConcept C175156509 @default.
- W2016984261 hasConcept C181199279 @default.
- W2016984261 hasConcept C182220744 @default.
- W2016984261 hasConcept C185592680 @default.
- W2016984261 hasConcept C197534660 @default.
- W2016984261 hasConcept C204787440 @default.
- W2016984261 hasConcept C2776157581 @default.
- W2016984261 hasConcept C2776164576 @default.
- W2016984261 hasConcept C2776224515 @default.
- W2016984261 hasConcept C2776714187 @default.
- W2016984261 hasConcept C2777265534 @default.
- W2016984261 hasConcept C2778259572 @default.
- W2016984261 hasConcept C2779939298 @default.
- W2016984261 hasConcept C3020332539 @default.