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- W2016985278 abstract "This study treated primarily the release characteristics of ephedrine from liquid emulsion systems as they were affected by the hydrophilic–lipophilic nature of the emulsifier present. Polysorbate 60 and sorbitan monostearate were varied by weight percent to produce emulsifiers having different hydrophilic–lipophilic balance (HLB) values. The experiments utilized a dialysis technique and consisted of seven controls plus the study of the emulsified systems throughout an HLB range of 4.7–14.9. The data indicated that the HLB value of the surfactants affected the release rate of ephedrine from an emulsified system, with the largest release rates occurring in the upper HLB range. The release of ephedrine from the oil phase was shown to be the rate-limiting step in its release from the emulsion. Surfactants did not impair the release of ephedrine from an oil system (control), whereas an inhibitory effect was noted in the water system (control). The data also indicated than an interfacial barrier was present in the emulsion and that ephedrine was released at two different rates from each of the various systems; the initial rate was greater than the second." @default.
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- W2016985278 date "1971-12-01" @default.
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- W2016985278 title "Influence of HLB Values of Surfactants on Ephedrine Release from Emulsified Liquid Systems" @default.
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- W2016985278 doi "https://doi.org/10.1002/jps.2600601212" @default.
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