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• W2016988195 abstract "β-Arrestin 2 as an adaptor plays a role in the regulation of receptor desensitization, trafficking, and signaling. Bovine β-arrestin 2 has been shown to be SUMOylated on the lysine 400 residue, which links it to the endocytosis of the β2-adrenergic receptor. Here we identify a major SUMOylation site, lysine 295, on human β-arrestin 2. SUMOylation on this site attenuates β-arrestin 2 binding to TRAF6, then enhances TRAF6 oligomerization and autoubiquitination, and consequently leads to the increase of TRAF6-mediated NF-κB/AP-1 activation. We further determine SENP1 as a specific de-SUMOylation protease that can reverse the SUMOylation of β-arrestin 2-mediated processes. Our study reveals SUMOylation as a novel mechanism in the regulation of β-arrestin 2-mediated IL-1R/TRAF6 signaling.It was unknown whether human β-arrestin 2 could be SUMOylated.ResultsHuman β-arrestin 2 is SUMOylated on Lys-295. SUMOylation attenuates β-arrestin 2 inhibition of IL-1R/TRAF6 signaling.ConclusionSUMOylation attenuates human β-arrestin 2 inhibition of TRAF6 and IL-1R signaling.SignificanceWe show SUMOylation as a novel mechanism in regulation of β-arrestin 2-mediated IL-1R-TRAF6 signaling. β-Arrestin 2 as an adaptor plays a role in the regulation of receptor desensitization, trafficking, and signaling. Bovine β-arrestin 2 has been shown to be SUMOylated on the lysine 400 residue, which links it to the endocytosis of the β2-adrenergic receptor. Here we identify a major SUMOylation site, lysine 295, on human β-arrestin 2. SUMOylation on this site attenuates β-arrestin 2 binding to TRAF6, then enhances TRAF6 oligomerization and autoubiquitination, and consequently leads to the increase of TRAF6-mediated NF-κB/AP-1 activation. We further determine SENP1 as a specific de-SUMOylation protease that can reverse the SUMOylation of β-arrestin 2-mediated processes. Our study reveals SUMOylation as a novel mechanism in the regulation of β-arrestin 2-mediated IL-1R/TRAF6 signaling.It was unknown whether human β-arrestin 2 could be SUMOylated. Human β-arrestin 2 is SUMOylated on Lys-295. SUMOylation attenuates β-arrestin 2 inhibition of IL-1R/TRAF6 signaling. SUMOylation attenuates human β-arrestin 2 inhibition of TRAF6 and IL-1R signaling." @default.
• W2016988195 created "2016-06-24" @default.
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• W2016988195 date "2015-01-01" @default.
• W2016988195 modified "2023-09-28" @default.
• W2016988195 title "SUMOylation Attenuates Human β-Arrestin 2 Inhibition of IL-1R/TRAF6 Signaling" @default.
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• W2016988195 doi "https://doi.org/10.1074/jbc.m114.608703" @default.
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