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• W2016990513 abstract "summary Massive blood loss due to penetrating trauma and internal organ damage can cause severe haemorrhagic shock (HS), leading to a severely compromised haemostatic balance. This study evaluated the effect of bovine polymerized haemoglobin (Hb) (Hb‐based oxygen carrier, HBOC) resuscitation on haemostasis in a swine model of uncontrolled HS. Following liver injury/HS, swine received HBOC ( n = 8), Hextend (HEX) ( n = 8) or no resuscitation (NON) ( n = 8). Fluids were infused to increase mean arterial pressure above 60 mmHg and to reduce heart rate to baseline. At 4 h, the animals were eligible for blood transfusions. Prothrombin time (PT), activated partial thromboplastin time, fibrinogen, thromboelastography (TEG) and platelet function analyser closure time (PFA‐CT) were compared by using mixed statistical model. At 4 h, blood loss (% estimated blood volume) was comparable for HBOC (65·5 ± 18·5%) and HEX (80·8 ± 14·4%) and less for NON (58·7 ± 10·1%; P < 0·05). Resuscitation‐induced dilutional coagulopathy was observed with HBOC and HEX, as indicated by reduced haematocrit, platelets and fibrinogen ( P < 0·05). At 4 h, PT was higher in HEX than in HBOC groups ( P < 0·01). In the early hospital phase, a trend to increased TEG reaction time and PFA‐CT indicates that dilutional effects persist in HBOC and HEX groups. PFA‐CT returned to baseline later with HBOC than with HEX (48 vs. 24 h) following blood transfusion. At 4 h, all surviving HEX animals ( n = 3) required transfusion, in contrast to no HBOC ( n = 7) or NON ( n = 1) animals. In this severe uncontrolled HS model, successful resuscitation with HBOC produced haemodilutional coagulopathy less than or similar to that produced by resuscitation with HEX." @default.
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• W2016990513 date "2006-07-25" @default.
• W2016990513 modified "2023-10-16" @default.
• W2016990513 title "Coagulation patterns following haemoglobin‐based oxygen carrier resuscitation in severe uncontrolled haemorrhagic shock in swine" @default.
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• W2016990513 doi "https://doi.org/10.1111/j.1365-3148.2006.00678.x" @default.
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