Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016994014> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2016994014 endingPage "452" @default.
- W2016994014 startingPage "444" @default.
- W2016994014 abstract "An in vitro model system has been developed in which freshly isolated resting WC1 + γ/δTcR + T cells proliferate in response to cells transformed by the protozoan parasite Theileria annulata , providing a strategy in which the basis of activation of naive γ/δ T cells can be investigated. Irradiated parasite‐transformed cells stimulate the proliferation, but not cytolytic activity, of autologous peripheral blood mononuclear cells (PBMC) from non‐immune animals. The proliferating cells are mainly WC1 + γ/δ T cells. The majority of WC1 + γ/δ T cells in freshly isolated PBMC express CD25 at a low level that increases when stimulated with T. annulata ‐infected cells. Purified WC1 + γ/δ T cells fail to proliferate when cultured with irradiated T. annulata ‐infected cells and produce a small proliferative response to IL‐2, but proliferate strongly to irradiated or lightly fixed Theileria ‐infected cells in combination with IL–2. The Theileria ‐infected cells express cytokine transcripts encoding IL‐1α, IL‐1β, IL‐6 and IL‐10, but not IFNγ, IL‐2, IL‐4 and IL–7. Purified WC1 + γ/δ T cells stimulated with T. annulata ‐infected cells with or without IL‐2 fail to produce IL‐2 transcripts, but do produce those for TNFα. These experiments show that WC1 + γ/δ T cells recognize a surface determinant on T. annulata ‐infected cells, that together with a second signal, which can be provided by exogenous IL‐2, stimulates their proliferation." @default.
- W2016994014 created "2016-06-24" @default.
- W2016994014 creator A5005184943 @default.
- W2016994014 creator A5032928491 @default.
- W2016994014 creator A5052535501 @default.
- W2016994014 creator A5070045376 @default.
- W2016994014 creator A5073650344 @default.
- W2016994014 date "1996-10-01" @default.
- W2016994014 modified "2023-10-03" @default.
- W2016994014 title "Bovine γ/δ TcR<sup>+</sup> T Lymphocytes are Stimulated to Proliferate by Autologous <i>Theileria annulata</i>‐Infected Cells in the Presence of Interleukin‐2" @default.
- W2016994014 doi "https://doi.org/10.1046/j.1365-3083.1996.d01-332.x" @default.
- W2016994014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8947595" @default.
- W2016994014 hasPublicationYear "1996" @default.
- W2016994014 type Work @default.
- W2016994014 sameAs 2016994014 @default.
- W2016994014 citedByCount "81" @default.
- W2016994014 countsByYear W20169940142012 @default.
- W2016994014 countsByYear W20169940142013 @default.
- W2016994014 countsByYear W20169940142014 @default.
- W2016994014 countsByYear W20169940142016 @default.
- W2016994014 countsByYear W20169940142019 @default.
- W2016994014 countsByYear W20169940142020 @default.
- W2016994014 countsByYear W20169940142021 @default.
- W2016994014 countsByYear W20169940142022 @default.
- W2016994014 countsByYear W20169940142023 @default.
- W2016994014 crossrefType "journal-article" @default.
- W2016994014 hasAuthorship W2016994014A5005184943 @default.
- W2016994014 hasAuthorship W2016994014A5032928491 @default.
- W2016994014 hasAuthorship W2016994014A5052535501 @default.
- W2016994014 hasAuthorship W2016994014A5070045376 @default.
- W2016994014 hasAuthorship W2016994014A5073650344 @default.
- W2016994014 hasConcept C129374314 @default.
- W2016994014 hasConcept C137061746 @default.
- W2016994014 hasConcept C149532602 @default.
- W2016994014 hasConcept C153911025 @default.
- W2016994014 hasConcept C154317977 @default.
- W2016994014 hasConcept C202751555 @default.
- W2016994014 hasConcept C203014093 @default.
- W2016994014 hasConcept C2776090121 @default.
- W2016994014 hasConcept C2777371288 @default.
- W2016994014 hasConcept C2778690821 @default.
- W2016994014 hasConcept C55493867 @default.
- W2016994014 hasConcept C79484868 @default.
- W2016994014 hasConcept C86803240 @default.
- W2016994014 hasConcept C8891405 @default.
- W2016994014 hasConcept C95444343 @default.
- W2016994014 hasConceptScore W2016994014C129374314 @default.
- W2016994014 hasConceptScore W2016994014C137061746 @default.
- W2016994014 hasConceptScore W2016994014C149532602 @default.
- W2016994014 hasConceptScore W2016994014C153911025 @default.
- W2016994014 hasConceptScore W2016994014C154317977 @default.
- W2016994014 hasConceptScore W2016994014C202751555 @default.
- W2016994014 hasConceptScore W2016994014C203014093 @default.
- W2016994014 hasConceptScore W2016994014C2776090121 @default.
- W2016994014 hasConceptScore W2016994014C2777371288 @default.
- W2016994014 hasConceptScore W2016994014C2778690821 @default.
- W2016994014 hasConceptScore W2016994014C55493867 @default.
- W2016994014 hasConceptScore W2016994014C79484868 @default.
- W2016994014 hasConceptScore W2016994014C86803240 @default.
- W2016994014 hasConceptScore W2016994014C8891405 @default.
- W2016994014 hasConceptScore W2016994014C95444343 @default.
- W2016994014 hasIssue "5" @default.
- W2016994014 hasLocation W20169940141 @default.
- W2016994014 hasLocation W20169940142 @default.
- W2016994014 hasOpenAccess W2016994014 @default.
- W2016994014 hasPrimaryLocation W20169940141 @default.
- W2016994014 hasRelatedWork W1830230921 @default.
- W2016994014 hasRelatedWork W2002809032 @default.
- W2016994014 hasRelatedWork W2020960833 @default.
- W2016994014 hasRelatedWork W2052493267 @default.
- W2016994014 hasRelatedWork W2066625284 @default.
- W2016994014 hasRelatedWork W2072972124 @default.
- W2016994014 hasRelatedWork W2117899905 @default.
- W2016994014 hasRelatedWork W2119122291 @default.
- W2016994014 hasRelatedWork W2326414761 @default.
- W2016994014 hasRelatedWork W2417599370 @default.
- W2016994014 hasVolume "44" @default.
- W2016994014 isParatext "false" @default.
- W2016994014 isRetracted "false" @default.
- W2016994014 magId "2016994014" @default.
- W2016994014 workType "article" @default.