FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016994512> ?p ?o ?g. }

• W2016994512 endingPage "1526" @default.
• W2016994512 startingPage "1520" @default.
• W2016994512 abstract "Activity-dependent regulation of synaptic efficacy is believed to underlie learning and memory formation. Here we show that protein degradation by the proteasome is required for the induction of the protein synthesis-dependent late-phase of long-term potentiation (late-LTP) but not for its maintenance. Proteasome activity was also key to the polarity of heterosynaptic interactions between synapses expressing synaptic plasticity and newly activated synapses. In fact, proteasome activity was required for the consolidation of an otherwise transient potentiation (early-LTP) into late-LTP by strong tetanization of a separate afferent pathway both in the weak-before-strong and in the strong-before-weak two-pathway paradigms [Frey and Morris (1997) Nature 385:533-536; Frey and Morris (1998) Neuropharmacology 37:545-552], suggesting that proteasome activity plays a role in the synaptic tagging and capture of plasticity-related proteins at stimulated synapses. Additionally, proteasome inhibition abrogated immunity against heterosynaptic depotentiation of an established late-LTP when applied during weak tetanic stimulation in the strong-before-weak two-pathway paradigm. Such a heterosynaptic destabilizing effect of proteasome inhibition was abolished by concomitant inhibition of N-methyl-d-aspartate (NMDA) receptors, suggesting that it is an active process. Together, these results indicate that the proteasome plays important roles in the establishment of late-LTP and in the preservation of potentiated synapses when a subsequent synaptic plasticity is induced within the same neuronal population." @default.
• W2016994512 created "2016-06-24" @default.
• W2016994512 creator A5036644252 @default.
• W2016994512 creator A5066810367 @default.
• W2016994512 creator A5071165085 @default.
• W2016994512 creator A5084945311 @default.
• W2016994512 date "2010-09-01" @default.
• W2016994512 modified "2023-10-14" @default.
• W2016994512 title "Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation" @default.
• W2016994512 cites W1525024462 @default.
• W2016994512 cites W1571281589 @default.
• W2016994512 cites W1964310366 @default.
• W2016994512 cites W1969147759 @default.
• W2016994512 cites W1973963032 @default.
• W2016994512 cites W1983532821 @default.
• W2016994512 cites W1994926162 @default.
• W2016994512 cites W1999488417 @default.
• W2016994512 cites W2011882079 @default.
• W2016994512 cites W2016118632 @default.
• W2016994512 cites W2016721540 @default.
• W2016994512 cites W2017197169 @default.
• W2016994512 cites W2023784360 @default.
• W2016994512 cites W2026663553 @default.
• W2016994512 cites W2032057219 @default.
• W2016994512 cites W2034713698 @default.
• W2016994512 cites W2038719756 @default.
• W2016994512 cites W2044005280 @default.
• W2016994512 cites W2049511526 @default.
• W2016994512 cites W2050658556 @default.
• W2016994512 cites W2050711545 @default.
• W2016994512 cites W2051716212 @default.
• W2016994512 cites W2063523634 @default.
• W2016994512 cites W2065716997 @default.
• W2016994512 cites W2106372172 @default.
• W2016994512 cites W2110724392 @default.
• W2016994512 cites W2118639179 @default.
• W2016994512 cites W2120383851 @default.
• W2016994512 cites W2127639747 @default.
• W2016994512 cites W2128134322 @default.
• W2016994512 cites W2131041787 @default.
• W2016994512 cites W2131979896 @default.
• W2016994512 cites W2132728901 @default.
• W2016994512 cites W2138247439 @default.
• W2016994512 cites W2155754506 @default.
• W2016994512 doi "https://doi.org/10.1016/j.neuroscience.2010.06.032" @default.
• W2016994512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20600658" @default.
• W2016994512 hasPublicationYear "2010" @default.
• W2016994512 type Work @default.
• W2016994512 sameAs 2016994512 @default.
• W2016994512 citedByCount "48" @default.
• W2016994512 countsByYear W20169945122012 @default.
• W2016994512 countsByYear W20169945122013 @default.
• W2016994512 countsByYear W20169945122014 @default.
• W2016994512 countsByYear W20169945122015 @default.
• W2016994512 countsByYear W20169945122016 @default.
• W2016994512 countsByYear W20169945122017 @default.
• W2016994512 countsByYear W20169945122018 @default.
• W2016994512 countsByYear W20169945122019 @default.
• W2016994512 countsByYear W20169945122020 @default.
• W2016994512 countsByYear W20169945122021 @default.
• W2016994512 countsByYear W20169945122022 @default.
• W2016994512 countsByYear W20169945122023 @default.
• W2016994512 crossrefType "journal-article" @default.
• W2016994512 hasAuthorship W2016994512A5036644252 @default.
• W2016994512 hasAuthorship W2016994512A5066810367 @default.
• W2016994512 hasAuthorship W2016994512A5071165085 @default.
• W2016994512 hasAuthorship W2016994512A5084945311 @default.
• W2016994512 hasConcept C160268369 @default.
• W2016994512 hasConcept C169760540 @default.
• W2016994512 hasConcept C170493617 @default.
• W2016994512 hasConcept C185592680 @default.
• W2016994512 hasConcept C194973443 @default.
• W2016994512 hasConcept C25274449 @default.
• W2016994512 hasConcept C27740335 @default.
• W2016994512 hasConcept C2776328245 @default.
• W2016994512 hasConcept C55493867 @default.
• W2016994512 hasConcept C67018056 @default.
• W2016994512 hasConcept C73009533 @default.
• W2016994512 hasConcept C86803240 @default.
• W2016994512 hasConcept C95444343 @default.
• W2016994512 hasConcept C98229152 @default.
• W2016994512 hasConceptScore W2016994512C160268369 @default.
• W2016994512 hasConceptScore W2016994512C169760540 @default.
• W2016994512 hasConceptScore W2016994512C170493617 @default.
• W2016994512 hasConceptScore W2016994512C185592680 @default.
• W2016994512 hasConceptScore W2016994512C194973443 @default.
• W2016994512 hasConceptScore W2016994512C25274449 @default.
• W2016994512 hasConceptScore W2016994512C27740335 @default.
• W2016994512 hasConceptScore W2016994512C2776328245 @default.
• W2016994512 hasConceptScore W2016994512C55493867 @default.
• W2016994512 hasConceptScore W2016994512C67018056 @default.
• W2016994512 hasConceptScore W2016994512C73009533 @default.
• W2016994512 hasConceptScore W2016994512C86803240 @default.
• W2016994512 hasConceptScore W2016994512C95444343 @default.
• W2016994512 hasConceptScore W2016994512C98229152 @default.
• W2016994512 hasFunder F4320321001 @default.
• W2016994512 hasFunder F4320337330 @default.
• W2016994512 hasFunder F4320337354 @default.

• next