FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016994976> ?p ?o ?g. }

• W2016994976 endingPage "S30" @default.
• W2016994976 startingPage "S23" @default.
• W2016994976 abstract "The ability of biphenyl-tetrazole angiotensin type 1 (AT1) receptor antagonists (BTsartans) to block angiotensin II (Ang II)-mediated responses has been extensively investigated in vascular tissues and, more recently, in cell lines expressing the human AT1-receptor. When pre-incubated, BTsartans acted surmountably (shifting the Ang II concentration-response curve to the right) or insurmountably (also decreasing the maximal response). It was shown that their insurmountable behaviour is due to the formation of tight, long-lasting complexes with the receptor. Partial insurmountable antagonism is due to the co-existence of tight and loose complexes. The proportion of insurmountable antagonism, the potency and the dissociation rate of the BTsartans decreases in the order: candesartan > EXP3174 (losartan's active metabolite) > valsartan > irbesartan >> losartan.It is of interest to explore how tight AT1-receptor binding of BTsartans such as candesartan might contribute to their long-lasting clinical effect.Computer-assisted simulations (COPASI program) were performed to follow the receptor-occupation and protection by different antagonists as a function of time. Free antagonist concentrations were allowed to decrease exponentially with time.The simulations suggest that slow dissociation does not tangibly prolong receptor occupancy if the free antagonist is eliminated at a slower pace (as is the case for BTsartans). Yet when surmountable and insurmountable antagonists occupy the same amount of receptors, insurmountable antagonists offer appreciably better protection against fluctuations in natural messenger concentration.Slow receptor dissociation and slow antagonist elimination are likely to act in synergy to produce long-lasting receptor protection." @default.
• W2016994976 created "2016-06-24" @default.
• W2016994976 creator A5061469672 @default.
• W2016994976 creator A5065113357 @default.
• W2016994976 creator A5084125169 @default.
• W2016994976 date "2006-03-01" @default.
• W2016994976 modified "2023-10-06" @default.
• W2016994976 title "Long-lasting angiotensin type 1 receptor binding and protection by candesartan: comparison with other biphenyl-tetrazole sartans" @default.
• W2016994976 cites W1749934866 @default.
• W2016994976 cites W1965521882 @default.
• W2016994976 cites W1974959226 @default.
• W2016994976 cites W1976633810 @default.
• W2016994976 cites W1979535634 @default.
• W2016994976 cites W1985042283 @default.
• W2016994976 cites W1998126138 @default.
• W2016994976 cites W1999181065 @default.
• W2016994976 cites W2002994521 @default.
• W2016994976 cites W2009802672 @default.
• W2016994976 cites W2016686407 @default.
• W2016994976 cites W2017561701 @default.
• W2016994976 cites W2020304135 @default.
• W2016994976 cites W2023077221 @default.
• W2016994976 cites W2024179544 @default.
• W2016994976 cites W2027521314 @default.
• W2016994976 cites W2029653823 @default.
• W2016994976 cites W2031418023 @default.
• W2016994976 cites W2033749858 @default.
• W2016994976 cites W2035737952 @default.
• W2016994976 cites W2052331738 @default.
• W2016994976 cites W2054479029 @default.
• W2016994976 cites W2056267722 @default.
• W2016994976 cites W2061743585 @default.
• W2016994976 cites W2067946831 @default.
• W2016994976 cites W2074008057 @default.
• W2016994976 cites W2076345901 @default.
• W2016994976 cites W2080697422 @default.
• W2016994976 cites W2089698436 @default.
• W2016994976 cites W2091261382 @default.
• W2016994976 cites W2092171289 @default.
• W2016994976 cites W2092556644 @default.
• W2016994976 cites W2095775529 @default.
• W2016994976 cites W2101780854 @default.
• W2016994976 cites W2104137617 @default.
• W2016994976 cites W2116259845 @default.
• W2016994976 cites W2117178285 @default.
• W2016994976 cites W2120331575 @default.
• W2016994976 cites W2122428188 @default.
• W2016994976 cites W2125256919 @default.
• W2016994976 cites W2126278865 @default.
• W2016994976 cites W2144335239 @default.
• W2016994976 cites W2159823385 @default.
• W2016994976 cites W2289785680 @default.
• W2016994976 cites W2321787823 @default.
• W2016994976 cites W2362789409 @default.
• W2016994976 doi "https://doi.org/10.1097/01.hjh.0000220403.61493.18" @default.
• W2016994976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16601569" @default.
• W2016994976 hasPublicationYear "2006" @default.
• W2016994976 type Work @default.
• W2016994976 sameAs 2016994976 @default.
• W2016994976 citedByCount "39" @default.
• W2016994976 countsByYear W20169949762012 @default.
• W2016994976 countsByYear W20169949762013 @default.
• W2016994976 countsByYear W20169949762014 @default.
• W2016994976 countsByYear W20169949762015 @default.
• W2016994976 countsByYear W20169949762016 @default.
• W2016994976 countsByYear W20169949762017 @default.
• W2016994976 countsByYear W20169949762018 @default.
• W2016994976 countsByYear W20169949762020 @default.
• W2016994976 countsByYear W20169949762021 @default.
• W2016994976 countsByYear W20169949762022 @default.
• W2016994976 countsByYear W20169949762023 @default.
• W2016994976 crossrefType "journal-article" @default.
• W2016994976 hasAuthorship W2016994976A5061469672 @default.
• W2016994976 hasAuthorship W2016994976A5065113357 @default.
• W2016994976 hasAuthorship W2016994976A5084125169 @default.
• W2016994976 hasConcept C104849204 @default.
• W2016994976 hasConcept C123915805 @default.
• W2016994976 hasConcept C126322002 @default.
• W2016994976 hasConcept C134018914 @default.
• W2016994976 hasConcept C170493617 @default.
• W2016994976 hasConcept C185592680 @default.
• W2016994976 hasConcept C2776885963 @default.
• W2016994976 hasConcept C2777387769 @default.
• W2016994976 hasConcept C2778122271 @default.
• W2016994976 hasConcept C2780036600 @default.
• W2016994976 hasConcept C2780288358 @default.
• W2016994976 hasConcept C2908929049 @default.
• W2016994976 hasConcept C71924100 @default.
• W2016994976 hasConcept C84393581 @default.
• W2016994976 hasConcept C86811712 @default.
• W2016994976 hasConcept C98274493 @default.
• W2016994976 hasConceptScore W2016994976C104849204 @default.
• W2016994976 hasConceptScore W2016994976C123915805 @default.
• W2016994976 hasConceptScore W2016994976C126322002 @default.
• W2016994976 hasConceptScore W2016994976C134018914 @default.
• W2016994976 hasConceptScore W2016994976C170493617 @default.
• W2016994976 hasConceptScore W2016994976C185592680 @default.
• W2016994976 hasConceptScore W2016994976C2776885963 @default.

• next